scholarly journals Role of Caveolin‐1 in Gastrointestinal Smooth Muscle Function

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Chereena T Clay ◽  
Sunila Mahavadi
Keyword(s):  
Smooth Muscle ◽  
Muscle Function ◽  
Caveolin 1 ◽  
Gastrointestinal Smooth Muscle ◽  
Smooth Muscle Function

Gallbladder motor function in gallstone patients: sonographic and in vitro studies on the role of gallstones, smooth muscle function and gallbladder wall inflammation

1994 ◽  
Vol 21 (3) ◽  
pp. 430-440 ◽  
Author(s):  
Piero Portincasa ◽  
Agostino Di Ciaula ◽  
Giuseppe Baldassarre ◽  
Vincenzo Palmieri ◽  
Antonia Gentile ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Motor Function ◽  
Muscle Function ◽  
Gallbladder Wall ◽  
In Vitro Studies ◽  
Smooth Muscle Function

The Role of Endogenous NADPH Oxidases in Airway and Pulmonary Vascular Smooth Muscle Function

2003 ◽  
Vol 5 (6) ◽  
pp. 751-758 ◽  
Author(s):  
John R. Hoidal ◽  
S.S. Brar ◽  
Anne B. Sturrock ◽  
Karl A. Sanders ◽  
Bruce Dinger ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Function ◽  
Nadph Oxidases ◽  
Smooth Muscle Function

Ambient particulate matter induces relaxation of rat aortic rings in vitro

2001 ◽  
Vol 20 (5) ◽  
pp. 259-265 ◽  
Author(s):  
A M Knaapen ◽  
G J den Hartog ◽  
A Bast ◽  
P JA Borm
Keyword(s):  
Smooth Muscle ◽  
Particulate Matter ◽  
Muscle Function ◽  
Ultrafine Particles ◽  
Epidemiological Studies ◽  
Suspended Particulate ◽  
Smooth Muscle Function ◽  
Underlying Mechanisms

Epidemiological studies have shown an association between ambient levels of particulate matter (PM) and increased mortality from cardiovascular diseases. However, the underlying mechanisms are still not clear. We hypothesised that PM, when translocated after inhalation, could affect vascular smooth muscle function. Therefore, total suspended particulate matter (TSP) was sampled and investigated for its ability to affect aortic muscle contraction. Both TSP and TSP supernatant (TSP-sup) induced a concentration-dependent relaxation of phenylephrine (PE)-precontracted aortic rings. Relaxation induced by 100 jg/ml TSP was 51.5 t 3.1% of total contraction. At 60 and 100 Hg/ ml, relaxation induced by TSP was significantly higher compared to TSP-sup. Ultrafine TiO2, used as a model to investigate the role of ultrafine particles, did not show an effect. Soluble iron, present in TSP suspensions, seems not to be involved, as chelating with deferoxamine did not affect TSP-induced relaxation. However, TSP effects were inhibited by Trolox, suggesting a role of oxidants. Nudation of aortic rings showed that effects of TSP were only partly endothelium-dependent, while preincubation with LNAME increased TSP-induced relaxation. From these data, we conclude that both the particle core and soluble components of TSP can affect the smooth muscle function, leading to changes in the vascular contractile response.

scholarly journals Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells

Physiology ◽  
2016 ◽  
Vol 31 (5) ◽  
pp. 316-326 ◽  
Author(s):  
Kenton M. Sanders ◽  
Yoshihiko Kito ◽  
Sung Jin Hwang ◽  
Sean M. Ward
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Function ◽  
Interstitial Cells Of Cajal ◽  
Smooth Muscles ◽  
Interstitial Cells ◽  
Gastrointestinal Smooth Muscle ◽  
Smooth Muscle Function ◽  
Cells Of Cajal ◽  
Regulatory Functions

Interstitial cells of mesenchymal origin form gap junctions with smooth muscle cells in visceral smooth muscles and provide important regulatory functions. In gastrointestinal (GI) muscles, there are two distinct classes of interstitial cells, c-Kit+interstitial cells of Cajal and PDGFRα+cells, that regulate motility patterns. Loss of these cells may contribute to symptoms in GI motility disorders.

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