scholarly journals Integration of photoacoustic imaging and high-intensity focused ultrasound

2010 ◽  
Vol 15 (2) ◽  
pp. 021312 ◽  
Author(s):  
Huizhong Cui ◽  
Jacob Staley ◽  
Xinmai Yang
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Photoacoustic Imaging ◽  
High Intensity Focused Ultrasound

scholarly journals Small PLGA nanocapsules Co-encapsulating copper sulfide nanodots and fluorocarbon compound for photoacoustic imaging-guided HIFU synergistic therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 4514-4524 ◽  
Author(s):  
Minghua Yao ◽  
Ming Ma ◽  
Huixiong Xu ◽  
Xiaoxia Pan ◽  
Guang Xu ◽  
...  
Keyword(s):  
High Intensity ◽  
Copper Sulfide ◽  
Focused Ultrasound ◽  
Photoacoustic Imaging ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Therapy ◽  
Organic Hybrid

A nanometer-sized inor-ganic/organic hybrid enhancement agent is constructed for photoacoustic imaging-guided high intensity focused ultrasound therapy.

scholarly journals Banoxantrone Coordinated Metal-Organic Framework for Photoacoustic Imaging-Guided High Intensity Focused Ultrasound Therapy

2021 ◽  
Author(s):  
Tingyu Sun ◽  
Jingnan Li ◽  
Chao Zeng ◽  
Chengyan Luo ◽  
Xirui Luo ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Photoacoustic Imaging ◽  
Metal Organic Framework ◽  
High Intensity Focused Ultrasound ◽  
Combination Regimen ◽  
Deep Tissue ◽  
Metal Organic ◽  
Specific Metal ◽  
Organic Framework

Abstract Background Photoacoustic imaging (PA) with high spatial resolution has great potential as desired monitoring means in the high intensity focused ultrasound (HIFU) surgery of tumor. However, its penetration depth in the tissue does not meet the clinical needs. Nanomedicine provides a new opportunity for PA imaging to guide HIFU surgery. Our studies found that hypoxic heterogeneity of tumor was effectively reversed by HIFU. Methods Herein, specific metal-organic framework nanosystem, constructed by coordination of banoxantrone (AQ4N) and Mn2+, is designed based on HIFU to reverse hypoxic heterogeneity of tumor. Results It could provide exogenous light-absorbing substances, thus improves the penetrability of PA imaging signal through the deep tissue and achieves clearer PA imaging for guiding HIFU surgery. In turn, AQ4N, in the hypoxic homogenous environment of tumor provided by HIFU, is activated sequentially to specifically treat the residual hypoxic tumor cells. Conclusions This strategy addresses the dissatisfaction of PA imaging-guided HIFU therapy and is promising for translation into a clinical combination regimen.

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