High Intensity
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2021 ◽  
Volodymyr I Chumakov ◽  
Mykhailo Ostryzhnyi ◽  
Oksana Kharchenko ◽  
Nataliya Rybalchenko ◽  
Vasiliy Muraveinyk ◽  

The results of experimental investigations of the effect of high-intensity pulsed UV radiation on reference strains of opportunistic pathogens S, aureus and E. coli are presented. The modified pulse UV sterilizer МПК-300-3 based on an end-face plasma accelerator was used as a radiation source, which provides a power pulsed discharge in an open atmosphere. The high efficiency of inactivation of the pathogens was provided within a short period of time. The possibility of providing urgent 100% sterilization of a pathogens has been shown. The prospects for the application of pulse sterilization technology to combat pathogens are considered.

2021 ◽  
Vol 54 (6) ◽  
Chris M. Fancher ◽  
Jeff R. Bunn ◽  
Jean Bilheux ◽  
Wenduo Zhou ◽  
Ross E. Whitfield ◽  

The pyRS (Python residual stress) analysis software was designed to address the data reduction and analysis needs of the High Intensity Diffractometer for Residual Stress Analysis (HIDRA) user community. pyRS implements frameworks for the calibration and reduction of measured 2D data into intensity versus scattering vector magnitude and subsequent single-peak-fitting analysis to facilitate texture and residual strain/stress analysis. pyRS components are accessible as standalone user interfaces for peak-fitting and stress/strain analysis or as Python scripts. The scripting interface facilitates automated data reduction and peak-fitting analysis using an autoreduction protocol. Details of the implemented functionality are discussed.

2021 ◽  
Vol 21 (1) ◽  
Anthony Venning ◽  
Tassia K. Oswald ◽  
Jeremy Stevenson ◽  
Nicci Tepper ◽  
Leva Azadi ◽  

Abstract Purpose Work can offer a myriad of social and health benefits. Long-term sick leave can be detrimental to employers, individuals, families, and societies. The burden of long-term sick leave has motivated the development of return to work (RTW) interventions. This study sought to determine what constitutes an effective psychosocial RTW intervention, which included exploring whether the level of intervention intensity and intervention characteristics matter to RTW outcomes. Methods A systematic review and narrative synthesis were undertaken. Studies were identified through six databases (Ovid Medline, CINAHL (EBSCOhost), PsycInfo (Ovid), ProQuest, Scopus, and Google Scholar) between 2011 and 3 September 2019. Randomised controlled trials (RCTs) or reviews published in English were eligible for inclusion if they targeted adults who were on sick leave/unemployed trying to return to full-capacity employment, had at least one structured psychosocial RTW intervention, and assessed RTW. Study quality was assessed using checklists from the Joanna Briggs Institute. Results Database searching yielded 12,311 records. Eighteen RCTs (comprising 42 intervention/comparison groups), seven reviews (comprising 153 studies), and five grey literature documents were included. Included studies were of moderate-to-high quality. Research was primarily conducted in Europe and focused on psychological or musculoskeletal problems. RTW outcomes included RTW status, time until RTW, insurance claims, and sick days. Participating in a RTW program was superior to care-as-usual. RTW outcomes were similar between diverse interventions of low, moderate, and high intensity. Common foundational characteristics seen across effective RTW interventions included a focus on RTW, psychoeducation, and behavioural activation. Conclusions Evidence suggests that a low intensity approach to RTW interventions may be an appropriate first option before investment in high intensity, and arguably more expensive interventions, as the latter appear to provide limited additional benefit. More high-quality RCTs, from diverse countries, are needed to provide stronger evidence.

2021 ◽  
Vol 11 (1) ◽  
Florian Recker ◽  
Marcus Thudium ◽  
Holger Strunk ◽  
Tolga Tonguc ◽  
Sara Dohmen ◽  

AbstractLittle is known about the specific anaesthesiological and multidisciplinary management of high-intensity focused ultrasound (HIFU) in uterine fibroids. This observational single-center study is the first reporting on an interdisciplinary approach to optimize outcome following ultrasound (US)-guided HIFU in German-speaking countries. A sample of forty patients with symptomatic uterine fibroids was treated by HIFU. Relevant treatment parameters such as total treatment time for intervention, anaesthesia, and sonication time as well as total energy, body temperature, peri-interventional medication and complications were analyzed. Interventional variables did not correlate significantly either with opioid dose or with body temperature. The average fibroid volume reduction rate was 37.8% ± 23.5%, 48.5% ± 22.0% and 70.2% ± 25.5% after 3, 6 and 12 months, respectively. No major anaesthesiological complications occurred apart from an epileptic seizure prior to HIFU treatment in one patient. Peri-procedural hyperthermia (> 37.5 °C) occurred in two patients. Post-procedural two patients experienced a sciatic nerve irritation up to one year; one patient with very large treated fibroid experienced strong short-lasting post-procedural pain. There were two complication-free pregnancies of HIFU-treated patients. Multidisciplinary management is crucial to optimize safety and outcome of US-guided HIFU for uterine fibroids. Peri-procedural pain and temperature management are critical points where an adequate collaboration between anesthesiologist and interventionalist is mandatory.

F1000Research ◽  
2021 ◽  
Vol 9 ◽  
pp. 624
Anthony Nicholls ◽  
Anthony Leicht ◽  
Jonathan Connor ◽  
Aaron Halliday ◽  
Kenji Doma

Background: : Rugby league involves repeated, complex, and high intensity change-of-direction (COD) movements with no existing test protocols that specifically assesses these multiple physical fitness components simultaneously. Thus, the current study examined the convergent validity of a repeated Illinois Agility (RIA) protocol with the repeated T-agility protocol, and the repeatability of the RIA protocol in adolescent Rugby League players. Furthermore, aerobic capacity and anaerobic and COD performance were assessed to determine whether these physical qualities were important contributors to the RIA protocol. Methods: Twenty-two junior Rugby League players completed 4 sessions with each separated by 7 days. Initially, physical fitness characteristics at baseline (i.e., Multi-stage Shuttle test, countermovement jump, 30-m sprint, single-effort COD and repeated sprint ability [RSA]) were assessed. The second session involved a familiarisation of RIA and repeated T-agility test (RTT) protocols. During the third and fourth sessions, participants completed the RIA and RTT protocols in a randomised, counterbalanced design to examine the validity and test-retest reliability of these protocols. Results: For convergent validity, significant correlations were identified between RIA and RTT performances (r= >0.80; p<0.05). For contributors to RIA performance, significant correlations were identified between all baseline fitness characteristics and RIA (r = >0.71; p < 0.05). Reliability of the RIA protocol was near perfect with excellent intra-class correlation coefficient (0.87-0.97), good ratio limits of agreement (×/÷ 1.05-1.06) and low coefficient of variations (1.8-2.0%). Conclusions: The current study has demonstrated the RIA to be a simple, valid and reliable field test for RL athletes that can provide coaches with information about their team’s ability to sustain high intensity, multi-directional running efforts.

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