AbstractConnectomics, the study of circuit architecture, has the potential to reveal the connectivity of any brain or brain area with single-synapse resolution. This is extremely exciting but at the same time quite daunting. The exciting part is obvious. The daunting part is less so, and relates to the challenge of extracting principles from overwhelming masses of high-resolution data. You might say that it is a nice problem to have, and I will agree. What I will argue here is that, if our goal is to derive from such data a general and theoretical understanding of the brain, wemust nowmore than ever take advantage of comparative approaches.
A brain-wide atlas of synapses across the mouse lifespan
