Maturation of the human cochlear amplifier: Distortion product otoacoustic emission suppression tuning curves recorded at low and high primary tone levels

2001 ◽  
Vol 110 (3) ◽  
pp. 1465-1476 ◽  
Author(s):  
Carolina Abdala
Keyword(s):  
Otoacoustic Emission ◽  
Cochlear Amplifier ◽  
Distortion Product Otoacoustic Emission ◽  
Tuning Curves ◽  
Distortion Product

scholarly journals Distortion-product otoacoustic emission suppression tuning curves in humans

2011 ◽  
Vol 129 (2) ◽  
pp. 817-827 ◽  
Author(s):  
Michael P. Gorga ◽  
Stephen T. Neely ◽  
Judy Kopun ◽  
Hongyang Tan
Keyword(s):  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Tuning Curves ◽  
Distortion Product

scholarly journals High-Frequency Cochlear Amplifier Dysfunction: A Dominating Contribution to the Cognitive-Ear Link

2022 ◽  
Vol 13 ◽  
Author(s):  
Yao Wang ◽  
Xiao Li ◽  
Fuxin Ren ◽  
Siqi Liu ◽  
Wen Ma ◽  
...  
Keyword(s):  
Linear Regression ◽  
High Frequency ◽  
Regression Models ◽  
Pure Tone ◽  
Otoacoustic Emission ◽  
Cochlear Amplifier ◽  
Linear Regression Models ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Multiple Linear Regression Models

Objective: The objective of this study was to investigate the role of the high-frequency cochlear dysfunction in the cognitive-ear link.Methods: Seventy-four presbycusis patients (PC group) and seventy-one age-, sex-, and education-level matched normal hearing controls (NH group) were recruited in this study. Participants underwent a battery of cognitive tests estimated by Montreal Cognitive Assessment (MoCA), Stroop Color-Word Interference Test (Stroop), Symbol Digit Modalities Test (SDMT), Auditory Verbal Learning Test (AVLT), and Trail-Making Test (TMT-A and B), as well as auditory tests including distortion product otoacoustic emission (DPOAE), pure tone (PT) thresholds, and speech reception thresholds (SRT). Data were analyzed using the factor analysis, partial correlation analysis, multiple linear regression models, and mediation models.Results: Distortion product otoacoustic emission detection amplitudes and PT thresholds performed worse gradually from low to high frequencies in both the NH and PC groups. High-frequency DPOAE (H-DPOAE) was significantly correlated with cognitive domains in the PC group (AVLT: r = 0.30, p = 0.04; SDMT: r = 0.36, p = 0.01; Stroop: r = –0.32, p = 0.03; TMT-A: r = –0.40, p = 0.005; TMT-B: r = –0.34, p = 0.02). Multiple linear regression models showed that H-DPOAE predicted cognitive impairment effectively for aspects of memory (R2 = 0.27, 95% CI, 0.03 to 1.55), attention (R2 = 0.32, 95% CI, –6.18 to –0.40), processing speed (R2 = 0.37, 95% CI, 0.20 to 1.64), and executive function (TMT-A: R2 = 0.34, 95% CI, –5.52 to 1.03; TMT-B: R2 = 0.29, 95% CI, –11.30 to –1.12). H-DPOAE directly affected cognition and fully mediated the relationship between pure tone average (PTA)/SRT and cognitive test scores, excluding MoCA.Conclusion: This study has demonstrated that the high-frequency cochlear amplifier dysfunction has a direct predictive effect on the cognitive decline and makes a large contribution to the cognitive-ear link.

scholarly journals Distortion-product otoacoustic emission suppression tuning curves in hearing-impaired humans

2012 ◽  
Vol 132 (5) ◽  
pp. 3292-3304 ◽  
Author(s):  
Alyson Gruhlke ◽  
Cori Birkholz ◽  
Stephen T. Neely ◽  
Judy Kopun ◽  
Hongyang Tan ◽  
...  
Keyword(s):  
Otoacoustic Emission ◽  
Hearing Impaired ◽  
Distortion Product Otoacoustic Emission ◽  
Tuning Curves ◽  
Distortion Product

scholarly journals An alternate approach to constructing distortion product otoacoustic emission (DPOAE) suppression tuning curves

2004 ◽  
Vol 116 (6) ◽  
pp. 3263-3266 ◽  
Author(s):  
Tiffany A. Johnson ◽  
Stephen T. Neely ◽  
Darcia M. Dierking ◽  
Brenda M. Hoover ◽  
Michael P. Gorga
Keyword(s):  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Tuning Curves ◽  
Distortion Product

Distortion product otoacoustic emission suppression tuning curves in normal-hearing and hearing-impaired human ears

2003 ◽  
Vol 114 (1) ◽  
pp. 263-278 ◽  
Author(s):  
Michael P. Gorga ◽  
Stephen T. Neely ◽  
Darcia M. Dierking ◽  
Patricia A. Dorn ◽  
Brenda M. Hoover ◽  
...  
Keyword(s):  
Otoacoustic Emission ◽  
Normal Hearing ◽  
Hearing Impaired ◽  
Distortion Product Otoacoustic Emission ◽  
Tuning Curves ◽  
Distortion Product

Distortion product otoacoustic emission suppression tuning curves in human adults and neonates

1996 ◽  
Vol 98 (1-2) ◽  
pp. 38-53 ◽  
Author(s):  
Carolina Abdala ◽  
Yvonne S. Sininger ◽  
Michael Ekelid ◽  
Fan-Gang Zeng
Keyword(s):  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Tuning Curves ◽  
Distortion Product ◽  
Human Adults

Pengaruh sisplatin dosis tinggi terhadap penurunan fungsi sel rambut luar koklea

2013 ◽  
Vol 40 (2) ◽  
Author(s):  
Asti Kristianti ◽  
Teti Madiadipoera ◽  
Bogi Soeseno
Keyword(s):  
Hair Cells ◽  
Malignant Neoplasm ◽  
Otoacoustic Emission ◽  
Outer Hair Cells ◽  
High Dose ◽  
Distortion Product Otoacoustic Emission ◽  
Inclusion Criteria ◽  
Cochlear Hair Cells ◽  
Distortion Product ◽  
Bilateral Sensorineural Hearing Loss

Background: Chemotherapy is worldwide used nowadays, and its toxicity still remain a problemespecially toxicity to the ear (ototoxicity). Cisplatin (cis-diamminedichloroplatinum) is one of themost commonly used chemotherapy and highly potent in treating epithelial malignancies. Ototoxicitycaused by cisplatin is irreversible, progressive, bilateral, sensorineural hearing loss especially on highfrequency (4-8 KHz) accompanied by tinnitus. Purpose: To observe the cochlear outer hair cells damagein malignancies patients treated with cisplatin. Methods: This study is an observational analytic studywith prospective design to determine the influence of high dose cisplatin on cochlear outer hair cellsfunction. The research was carried out at the ENT-HNS Department, Hasan Sadikin General HospitalBandung, from November 2007 until June 2008. Audiometry, tympanometry, and distortion productotoacoustic emission (DPOAE) examinations were conducted before chemotherapy and DPOAE, andtimpanometry was again measured three days after first and second cycles of cisplatin administration. McNemar test was performed to calculate the effects of high-dose cisplatin to the cochlear outer haircells function. To compare pre and post-cisplatin on alteration of cochlear hair cells function, Wilcoxontest was used. Results: In this study 60 ears from 30 subjects that meet the inclusion criteria, consistedof 25 man (83.3%) and 5 women (16.7%). The prevalence of damaged cochlear outer hair cells were63% at first cycle and 70% at second cycle of cisplatin administration. The decline of cochlear outerhair cells function was significant (p<0.001). Conclusion: High-dose cisplatin decreases cochlear outerhair cells function in patients with malignant neoplasm. Abstrak : Latar belakang: Kemoterapi sekarang rutin digunakan secara klinis di seluruh dunia. Sejalan denganhal tersebut toksisitas kemoterapi, khususnya terhadap telinga saat ini menjadi perhatian. Sisplatin(cis-diamminedichloroplatinum) adalah salah satu obat kemoterapi yang paling banyak digunakandan paling manjur untuk terapi keganasan epitelial. Efek ototoksik sisplatin yaitu terjadi gangguandengar sensorineural yang irreversible, progresif, bilateral pada frekuensi tinggi (4-8 kHz), dan disertaidengan tinitus. Tujuan: Untuk menilai penurunan fungsi sel rambut luar koklea pada penderita tumorganas sesudah pemberian sisplatin dosis tinggi dengan menggunakan DPOAE. Metode: Studi analitikobservasional dengan rancangan prospektif di Bagian IK. THT-KL RS. Hasan Sadikin Bandung mulaibulan November 2007 sampai dengan Juni 2008. Pada penelitian ini dilakukan pemeriksaan audiometrinada murni, timpanometri, dan distortion product otoacoustic emission (DPOAE) prakemoterapi, kemudianDPOAE dan timpanometri diulang tiga hari sesudah siklus pertama dan kedua kemoterapi sisplatin. Datayang diperoleh diuji dengan uji McNemar dan uji Wilcoxon. Hasil: Dari penelitian didapat 60 telingadari 30 subjek penelitian yang memenuhi kriteria inklusi yang terdiri dari 25 laki-laki (83,3%) dan 5perempuan (16,7%). Insidens penurunan fungsi sel rambut luar koklea sebesar 63% (38 kasus) sesudahsiklus pertama dan 70% (42 kasus) sesudah siklus kedua. Hubungan penurunan fungsi sel rambut luarkoklea memberikan nilai yang sangat bermakna sejak pemberian siklus pertama (p<0,001). Kesimpulan:Pemberian sisplatin dosis tinggi pada penderita tumor ganas menyebabkan penurunan fungsi sel rambutluar koklea.Kata kunci: kemoterapi, sisplatin dosis tinggi, sel rambut luar koklea.

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