Rehabilitation After Oswestry Autologous-Chondrocyte Implantation: The OsCell Protocol

2003 ◽  
Vol 12 (2) ◽  
pp. 104-118 ◽  
Author(s):  
Andrea Bailey ◽  
Nicola Goodstone ◽  
Sharon Roberts ◽  
Jane Hughes ◽  
Simon Roberts ◽  
...  
Keyword(s):  
Autologous Chondrocyte Implantation ◽  
Weight Bearing ◽  
Critical Role ◽  
Data Sources ◽  
Cartilage Defects ◽  
Postoperative Rehabilitation ◽  
Data Synthesis ◽  
Chondrocyte Implantation ◽  
Type Data ◽  
Autologous Chondrocyte

Objective:To develop a postoperative rehabilitation protocol for patients receiving autologous-chondrocyte implantation (ACI) to repair articular-cartilage defects of the knee.Data Sources:careful review of both basic science and clinical literature, personal communication with colleagues dealing with similar cases, and the authors’ experience and expertise in rehabilitating numerous patients with knee pathologies, injuries, and trauma.Data Synthesis:Postoperative rehabilitation of the ACI patient plays a critical role in the outcome of the procedure. The goals are to improve function and reduce discomfort by focusing on 3 key elements: weight bearing, range of motion, and strengthening.Conclusions:The authors present 2 flexible postoperative protocols to rehabilitate patients after an ACI procedure to the knee.

scholarly journals The Evolution of Progressive Postoperative Weight Bearing After Autologous Chondrocyte Implantation in the Tibiofemoral Joint

2014 ◽  
Vol 23 (3) ◽  
pp. 192-202 ◽  
Author(s):  
Jay R. Ebert ◽  
Peter K. Edwards
Keyword(s):  
Autologous Chondrocyte Implantation ◽  
Weight Bearing ◽  
Treatment Algorithm ◽  
Surgical Techniques ◽  
Optimal Level ◽  
Full Weight Bearing ◽  
Cartilage Defects ◽  
Chondrocyte Implantation ◽  
Partial Weight ◽  
Autologous Chondrocyte

Autologous chondrocyte implantation (ACI) has demonstrated good clinical success in the repair of articular cartilage defects in the knee. Postoperative rehabilitation after ACI is considered critical in returning the patient to an optimal level of function by attempting to create the appropriate mechanical environment for cartilage regrowth, and it involves a progressive program that emphasizes full motion, progressive partial weight bearing (PWB), and controlled exercises. While evidence-based research is clearly lacking in all components of ACI rehabilitation, one important element in this treatment algorithm that has been subjected to some early scientific study is the gradual progression of the patient back to full weight-bearing (WB) gait after surgery. With the continual advancement of ACI surgical techniques, along with clinical experience and improved knowledge of histology and of the maturation process of chondrocytes, proposed postoperative WB protocols have evolved to better reflect the nature of the specific ACI surgery. The purpose of this article is to present the varied PWB programs that have been practiced alongside the evolving ACI surgical technique, the experimental basis for such protocols, the issues pertinent to the accurate prescription of WB, and future directions for developing such methods to best return patients to an optimal level of function after ACI.

scholarly journals Regenerative Medicine: A Review of the Evolution of Autologous Chondrocyte Implantation (ACI) Therapy

2019 ◽  
Vol 6 (1) ◽  
pp. 22 ◽  
Author(s):  
Rebecca Davies ◽  
Nicola Kuiper
Keyword(s):  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Autologous Chondrocyte Implantation ◽  
Weight Bearing ◽  
Cartilage Defects ◽  
Chondrocyte Implantation ◽  
Established Cell ◽  
Open Joint ◽  
Articular Cartilage Defects ◽  
Autologous Chondrocyte

Articular cartilage is composed of chondrons within a territorial matrix surrounded by a highly organized extracellular matrix comprising collagen II fibrils, proteoglycans, glycosaminoglycans, and non-collagenous proteins. Damaged articular cartilage has a limited potential for healing and untreated defects often progress to osteoarthritis. High hopes have been pinned on regenerative medicine strategies to meet the challenge of preventing progress to late osteoarthritis. One such strategy, autologous chondrocyte implantation (ACI), was first reported in 1994 as a treatment for deep focal articular cartilage defects. ACI has since evolved to become a worldwide well-established surgical technique. For ACI, chondrocytes are harvested from the lesser weight bearing edge of the joint by arthroscopy, their numbers expanded in monolayer culture for at least four weeks, and then re-implanted in the damaged region under a natural or synthetic membrane via an open joint procedure. We consider the evolution of ACI to become an established cell therapy, its current limitations, and on-going strategies to improve its efficacy. The most promising developments involving cells and natural or synthetic biomaterials will be highlighted.

scholarly journals What Patients Expect About Autologous Chondrocyte Implantation (ACI) for Treatment of Cartilage Defects at the Knee Joint

Cartilage ◽  
2012 ◽  
Vol 3 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Philipp Niemeyer ◽  
Stella Porichis ◽  
Gian Salzmann ◽  
Norbert P. Südkamp
Keyword(s):  
Knee Joint ◽  
Autologous Chondrocyte Implantation ◽  
Cartilage Defects ◽  
Chondrocyte Implantation ◽  
Autologous Chondrocyte
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