STRUCTURAL ELUCIDATION OF HYDROXYLATED METABOLITES OF THE ISOFLAVAN EQUOL BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY

2005 ◽  
Vol 34 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Corinna E. Rüfer ◽  
Hansruedi Glatt ◽  
Sabine E. Kulling
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Structural Elucidation ◽  
Gas Chromatography Mass Spectrometry ◽  
Liquid Chromatography Mass Spectrometry ◽  
Hydroxylated Metabolites ◽  
Chromatography Mass Spectrometry

Detection of Bromisovalum from the Bone Marrow of Skeletonized Human Remains: A Case Report with a Comparison between Gas Chromatography/Mass Spectrometry (GC/MS) and High-Performance Liquid Chromatography/Mass Spectrometry (LC/MS)

1997 ◽  
Vol 37 (3) ◽  
pp. 248-253 ◽  
Author(s):  
H Maeda ◽  
S Oritani ◽  
K Nagai ◽  
T Tanaka ◽  
N Tanaka
Keyword(s):  
Mass Spectrometry ◽  
Bone Marrow ◽  
Gas Chromatography ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Gas Chromatography Mass Spectrometry ◽  
Post Mortem ◽  
Liquid Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry

We report a case of totally skeletonized human remains in which a considerable amount of a hypnotic, bromisovalum (bromovalerylurea), was detected from the bone marrow. The unknown skeletal remains were found in a bush, together with empty vials of bromisovalum and a water bottle. The body was identified as a 46-year-old male, who had died about seven months previously. There was no evidence of trauma. The dried bone marrow of both femurs was separately collected and toxicologically analysed by gas chromatography/mass spectrometry (GC/MS) and high-performance liquid chromatography/mass spectrometry (LC/MS). Bromisovalum was identified from the femurs. The concentration along with the circumstantial evidence suggested possible contribution of bromisovalum to the fatality. However, a considerable quantitative difference was observed between the left and right femur, showing significant post-mortem interference to toxicological evidence. The result showed that multiple sampling at least would be required for quantitative evaluation of post-mortem toxicological evidence. Moreover, the diagnostic value should also be considered with caution in relation to the blood to bone marrow ratio of each drug concentration.

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