scholarly journals Cytochrome P450 Regulation by α-Tocopherol in Pxr-Null and PXR-Humanized Mice

2012 ◽  
Vol 41 (2) ◽  
pp. 406-413 ◽  
Author(s):  
Caroline H. Johnson ◽  
Jessica A. Bonzo ◽  
Jie Cheng ◽  
Kristopher W. Krausz ◽  
Dong Wook Kang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Humanized Mice

scholarly journals Altered Expression of Small Heterodimer Partner Governs Cytochrome P450 (CYP) 2D6 Induction during Pregnancy in CYP2D6-humanized Mice

2013 ◽  
Vol 289 (6) ◽  
pp. 3105-3113 ◽  
Author(s):  
Kwi Hye Koh ◽  
Xian Pan ◽  
Hong-Wu Shen ◽  
Samuel L. M. Arnold ◽  
Ai-Ming Yu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Humanized Mice ◽  
Altered Expression ◽  
Small Heterodimer Partner ◽  
Cyp 2D6

scholarly journals Krüppel-Like Factor 9 Promotes Hepatic Cytochrome P450 2D6 Expression during Pregnancy in CYP2D6-Humanized Mice

2014 ◽  
Vol 86 (6) ◽  
pp. 727-735 ◽  
Author(s):  
Kwi Hye Koh ◽  
Xian Pan ◽  
Wei Zhang ◽  
Alan McLachlan ◽  
Raul Urrutia ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Humanized Mice ◽  
Cytochrome P450 2D6 ◽  
P450 2D6 ◽  
Hepatic Cytochrome

Cytochrome P450 Expression and Regulation in CYP3A4/CYP2D6 Double Transgenic Humanized Mice

2007 ◽  
Vol 36 (2) ◽  
pp. 435-441 ◽  
Author(s):  
Melanie A. Felmlee ◽  
Hoi-Kei Lon ◽  
Frank J. Gonzalez ◽  
Ai-Ming Yu
Keyword(s):  
Cytochrome P450 ◽  
Humanized Mice ◽  
P450 Expression

In Vitro Evaluation of Cytochrome P450 and Glucuronidation Activities in Hepatocytes Isolated from Liver-Humanized Mice

2010 ◽  
Vol 25 (6) ◽  
pp. 539-550 ◽  
Author(s):  
Chihiro Yamasaki ◽  
Miho Kataoka ◽  
Yumiko Kato ◽  
Masakazu Kakuni ◽  
Sadakazu Usuda ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Humanized Mice ◽  
In Vitro Evaluation

scholarly journals Effects of Oridonin on Hepatic Cytochrome P450 Expression and Activities in PXR-Humanized Mice

2018 ◽  
Vol 41 (5) ◽  
pp. 707-712 ◽  
Author(s):  
Zhang Yi-wen ◽  
Bao Mei-hua ◽  
Lou Xiao-ya ◽  
Cheng Yu ◽  
Yu Jing ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Humanized Mice ◽  
P450 Expression ◽  
Hepatic Cytochrome

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

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