scholarly journals Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates via a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice

2019 ◽  
Vol 42 (3) ◽  
pp. 348-353 ◽  
Author(s):  
Ryuji Watari ◽  
Motoharu Kakiki ◽  
Chihiro Yamasaki ◽  
Yuji Ishida ◽  
Chise Tateno ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Hepatic Clearance ◽  
Culture Method ◽  
Humanized Mice ◽  
Collagen Vitrigel

scholarly journals Altered Expression of Small Heterodimer Partner Governs Cytochrome P450 (CYP) 2D6 Induction during Pregnancy in CYP2D6-humanized Mice

2013 ◽  
Vol 289 (6) ◽  
pp. 3105-3113 ◽  
Author(s):  
Kwi Hye Koh ◽  
Xian Pan ◽  
Hong-Wu Shen ◽  
Samuel L. M. Arnold ◽  
Ai-Ming Yu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Humanized Mice ◽  
Altered Expression ◽  
Small Heterodimer Partner ◽  
Cyp 2D6

scholarly journals Cytochrome P450 Regulation by α-Tocopherol in Pxr-Null and PXR-Humanized Mice

2012 ◽  
Vol 41 (2) ◽  
pp. 406-413 ◽  
Author(s):  
Caroline H. Johnson ◽  
Jessica A. Bonzo ◽  
Jie Cheng ◽  
Kristopher W. Krausz ◽  
Dong Wook Kang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Humanized Mice

scholarly journals Krüppel-Like Factor 9 Promotes Hepatic Cytochrome P450 2D6 Expression during Pregnancy in CYP2D6-Humanized Mice

2014 ◽  
Vol 86 (6) ◽  
pp. 727-735 ◽  
Author(s):  
Kwi Hye Koh ◽  
Xian Pan ◽  
Wei Zhang ◽  
Alan McLachlan ◽  
Raul Urrutia ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Humanized Mice ◽  
Cytochrome P450 2D6 ◽  
P450 2D6 ◽  
Hepatic Cytochrome

scholarly journals Profiling of hepatic clearance pathways of Pittsburgh compound B and human liver cytochrome p450 phenotyping

2013 ◽  
Vol 3 (1) ◽  
pp. 10 ◽  
Author(s):  
Anne Van Vlaslaer ◽  
Russell J Mortishire-Smith ◽  
Claire Mackie ◽  
Xavier Langlois ◽  
Mark E Schmidt
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Hepatic Clearance ◽  
Pittsburgh Compound B ◽  
Liver Cytochrome

Cytochrome P450 Expression and Regulation in CYP3A4/CYP2D6 Double Transgenic Humanized Mice

2007 ◽  
Vol 36 (2) ◽  
pp. 435-441 ◽  
Author(s):  
Melanie A. Felmlee ◽  
Hoi-Kei Lon ◽  
Frank J. Gonzalez ◽  
Ai-Ming Yu
Keyword(s):  
Cytochrome P450 ◽  
Humanized Mice ◽  
P450 Expression
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