Correction to: “PBPK Modeling to Unravel Nonlinear Pharmacokinetics of Verapamil to Estimate the Fractional Clearance for Verapamil N-Demethylation in the Recirculating Rat Liver Preparation”

2015 ◽  
Vol 43 (7) ◽  
pp. 1060-1060
Keyword(s):  
Rat Liver ◽  
Nonlinear Pharmacokinetics ◽  
Pbpk Modeling ◽  
Fractional Clearance ◽  
Liver Preparation

Kinetics of sulfation and glucuronidation of harmol in the perfused rat liver preparation

1982 ◽  
Vol 31 (19) ◽  
pp. 3023-3028 ◽  
Author(s):  
Henk Koster ◽  
Ina Halsema ◽  
Egbert Scholtens ◽  
K.Sandy Pang ◽  
Gerard J. Mulder
Keyword(s):  
Rat Liver ◽  
Perfused Rat Liver ◽  
Liver Preparation ◽  
Kinetics Of

scholarly journals Hemodynamics of the Vascular Tree of the Isolated Rat Liver Preparation

1956 ◽  
Vol 186 (3) ◽  
pp. 537-542 ◽  
Author(s):  
Ralph W. Brauer ◽  
G. F. Leong ◽  
R. F. McElroy ◽  
R. J. Holloway
Keyword(s):  
Rat Liver ◽  
Liver Blood Flow ◽  
Liver Weight ◽  
Rat Plasma ◽  
Nonlinear Flow ◽  
Isolated Rat Liver ◽  
Vascular Bed ◽  
Liver Preparation ◽  
Flow Pressure ◽  
Isolated Rat

The hemodynamic properties of the hepatic vascular bed of the isolated rat liver preparation have been studied by the use of flow-pressure diagrams in experiments involving as a perfusate either whole blood or cell-free rat plasma under an oxygen partial pressure of 2.5 atm. Either perfusion medium yields a nonlinear flow-pressure diagram of sigmoid shape approaching a straight line through the origin at perfusion pressures slightly above physiological ones. Data are also reported concerning change of liver weight with perfusion pressure of the isolated organ. These, together with previously reported results of radiocolloid uptake studies, are incorporated into a representation of the hepatic vascular bed in terms of a population of parallel vascular channels having critical opening pressures distributed between 7 and 13 cm of plasma. The distribution function is described and its bearing upon liver function in relation to liver blood flow is briefly discussed.

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