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Pharmacokinetics and Catabolism of [3H]TAK-164, a Guanylyl Cyclase C Targeted Antibody-Drug Conjugate
Drug Metabolism and Disposition
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10.1124/dmd.120.000194
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2020
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Vol 48
(11)
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pp. 1239-1245
Author(s):
Jayaprakasam Bolleddula
◽
Abhi Shah
◽
Mohammad Shadid
◽
Afrand Kamali
◽
Michael D. Smith
◽
...
Keyword(s):
Guanylyl Cyclase
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Guanylyl Cyclase C
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Antibody Drug Conjugate
◽
Drug Conjugate
◽
Antibody Drug
Download Full-text
Related Documents
Cited By
References
Abstract 3916: Relationship of guanylyl cyclase C (GCC) expression and efficacy of TAK-164, a GCC-targeted antibody-drug conjugate in a panel of 68 subcutaneous HuPrime colorectal cancer PDX models
10.1158/1538-7445.am2018-3916
◽
2018
◽
Cited By ~ 1
Author(s):
Erik M. Koenig
◽
Cong Li
◽
Huyuan Yang
◽
Andy Zhu
◽
Pooja Shah
◽
...
Keyword(s):
Colorectal Cancer
◽
Guanylyl Cyclase
◽
Guanylyl Cyclase C
◽
Antibody Drug Conjugate
◽
Drug Conjugate
◽
Relationship Of
◽
Pdx Models
◽
Antibody Drug
Download Full-text
Phase II study of the antibody-drug conjugate TAK-264 (MLN0264) in patients with metastatic or recurrent adenocarcinoma of the stomach or gastroesophageal junction expressing guanylyl cyclase C
Investigational New Drugs
◽
10.1007/s10637-017-0439-y
◽
2017
◽
Vol 35
(2)
◽
pp. 235-241
◽
Cited By ~ 8
Author(s):
Khaldoun Almhanna
◽
Maria Luisa Limon Miron
◽
David Wright
◽
Antonio Cubillo Gracian
◽
Richard A. Hubner
◽
...
Keyword(s):
Phase Ii
◽
Guanylyl Cyclase
◽
Phase Ii Study
◽
Gastroesophageal Junction
◽
Guanylyl Cyclase C
◽
Antibody Drug Conjugate
◽
Drug Conjugate
◽
Antibody Drug
Download Full-text
Abstract PR12: MLN0264, an investigational, first-in-class antibody-drug conjugate (ADC) targeting guanylyl cyclase C (GCC), demonstrates antitumor activity alone and in combination with gemcitabine in human pancreatic cancer xenograft models expressing GCC.
10.1158/1535-7163.targ-13-pr12
◽
2013
◽
Cited By ~ 4
Author(s):
Julie Zhang
◽
Melissa Gallery
◽
Tim Wyant
◽
Brad Stringer
◽
Mark Manfredi
◽
...
Keyword(s):
Pancreatic Cancer
◽
Antitumor Activity
◽
Guanylyl Cyclase
◽
Human Pancreatic Cancer
◽
Guanylyl Cyclase C
◽
Antibody Drug Conjugate
◽
Drug Conjugate
◽
Xenograft Models
◽
Class Antibody
◽
Antibody Drug
Download Full-text
Phase I Study of the Investigational Anti-Guanylyl Cyclase C (GCC) Antibody-Drug Conjugate (ADC) Mln0264 in Adult Patients with Advanced Gastrointestinal Malignancies Expressing GCC
Annals of Oncology
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10.1093/annonc/mdu193.9
◽
2014
◽
Vol 25
◽
pp. ii108
◽
Cited By ~ 1
Author(s):
J.E. Faris
◽
C. Cruz
◽
K. Almhanna
◽
W. Messersmith
◽
J. Rodon
◽
...
Keyword(s):
Phase I
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Guanylyl Cyclase
◽
Phase I Study
◽
Adult Patients
◽
Guanylyl Cyclase C
◽
Antibody Drug Conjugate
◽
Gastrointestinal Malignancies
◽
Drug Conjugate
◽
Antibody Drug
Download Full-text
Abstract 4649: Using pharmacokinetic/efficacy modeling to identify the optimal schedule for MLN0264, an anti- guanylyl cyclase C (GCC) antibody-drug conjugate, in a range of xenograft models
10.1158/1538-7445.am2014-4649
◽
2014
◽
Cited By ~ 1
Author(s):
Shu-Wen Teng
◽
Christopher Zopf
◽
Johnny Yang
◽
Brad Stringer
◽
Julie Zhang
◽
...
Keyword(s):
Guanylyl Cyclase
◽
Optimal Schedule
◽
Guanylyl Cyclase C
◽
Antibody Drug Conjugate
◽
Drug Conjugate
◽
Xenograft Models
◽
Antibody Drug
Download Full-text
Mln0264, an Investigational, First-In-Class Antibody-Drug Conjugate Targeting Guanylyl Cyclase C (Gcc): First-In-Human Study in Patients with Advanced Gastrointestinal Malignancies
Annals of Oncology
◽
10.1093/annonc/mdt202.30
◽
2013
◽
Vol 24
◽
pp. iv36
◽
Cited By ~ 2
Author(s):
Wells Messersmith
◽
Khaldoun Almhanna
◽
Jordi Rodon
◽
Cristina Cruz
◽
David Ryan
◽
...
Keyword(s):
Guanylyl Cyclase
◽
Human Study
◽
Guanylyl Cyclase C
◽
Antibody Drug Conjugate
◽
Gastrointestinal Malignancies
◽
Drug Conjugate
◽
Class Antibody
◽
Antibody Drug
Download Full-text
Abstract CT117: A phase II trial of TAK-264, a novel antibody-drug conjugate (ADC), in patients with pancreatic adenocarcinoma expressing guanylyl cyclase C (GCC)
10.1158/1538-7445.am2016-ct117
◽
2016
◽
Author(s):
Khaldoun Almhanna
◽
David Wright
◽
Teresa Macarulla Mercadé
◽
Jean-Luc Van Laethem
◽
Antonio Cubillo Gracian
◽
...
Keyword(s):
Pancreatic Adenocarcinoma
◽
Phase Ii
◽
Guanylyl Cyclase
◽
Phase Ii Trial
◽
Guanylyl Cyclase C
◽
Antibody Drug Conjugate
◽
Drug Conjugate
◽
Antibody Drug
Download Full-text
A phase II study of antibody-drug conjugate, TAK-264 (MLN0264) in previously treated patients with advanced or metastatic pancreatic adenocarcinoma expressing guanylyl cyclase C
Investigational New Drugs
◽
10.1007/s10637-017-0473-9
◽
2017
◽
Vol 35
(5)
◽
pp. 634-641
◽
Cited By ~ 8
Author(s):
Khaldoun Almhanna
◽
David Wright
◽
Teresa Macarulla Mercade
◽
Jean-Luc Van Laethem
◽
Antonio Cubillo Gracian
◽
...
Keyword(s):
Pancreatic Adenocarcinoma
◽
Phase Ii
◽
Guanylyl Cyclase
◽
Phase Ii Study
◽
Guanylyl Cyclase C
◽
Antibody Drug Conjugate
◽
Metastatic Pancreatic Adenocarcinoma
◽
Previously Treated Patients
◽
Previously Treated
◽
Antibody Drug
Download Full-text
Antibody–drug conjugate directed against the guanylyl cyclase antigen for the treatment of gastrointestinal malignancies
Pharmacology & Therapeutics
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10.1016/j.pharmthera.2016.10.007
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2017
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Vol 170
◽
pp. 8-13
◽
Cited By ~ 4
Author(s):
Khaldoun Almhanna
◽
Gopi K. Prithviraj
◽
Petter Veiby
◽
Thea Kalebic
Keyword(s):
Guanylyl Cyclase
◽
Antibody Drug Conjugate
◽
Gastrointestinal Malignancies
◽
Drug Conjugate
◽
Antibody Drug
Download Full-text
Phase I Study of the Investigational Anti-Guanylyl Cyclase Antibody–Drug Conjugate TAK-264 (MLN0264) in Adult Patients with Advanced Gastrointestinal Malignancies
Clinical Cancer Research
◽
10.1158/1078-0432.ccr-15-2474
◽
2016
◽
Vol 22
(20)
◽
pp. 5049-5057
◽
Cited By ~ 17
Author(s):
Khaldoun Almhanna
◽
Thea Kalebic
◽
Cristina Cruz
◽
Jason E. Faris
◽
David P. Ryan
◽
...
Keyword(s):
Phase I
◽
Guanylyl Cyclase
◽
Phase I Study
◽
Adult Patients
◽
Antibody Drug Conjugate
◽
Gastrointestinal Malignancies
◽
Drug Conjugate
◽
Antibody Drug
Download Full-text
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