Phase II study of the antibody-drug conjugate TAK-264 (MLN0264) in patients with metastatic or recurrent adenocarcinoma of the stomach or gastroesophageal junction expressing guanylyl cyclase C

Khaldoun Almhanna; Maria Luisa Limon Miron; David Wright; Antonio Cubillo Gracian; Richard A. Hubner; Jean-Luc Van Laethem; Carolina Muriel López; Maria Alsina; Frederico Longo Muñoz; Johanna Bendell; Irfan Firdaus; Wells Messersmith; Zhan Ye; Adedigbo A. Fasanmade; Hadi Danaee; Thea Kalebic

doi:10.1007/s10637-017-0439-y

Phase II study of the antibody-drug conjugate TAK-264 (MLN0264) in patients with metastatic or recurrent adenocarcinoma of the stomach or gastroesophageal junction expressing guanylyl cyclase C

Investigational New Drugs ◽

10.1007/s10637-017-0439-y ◽

2017 ◽

Vol 35 (2) ◽

pp. 235-241 ◽

Cited By ~ 8

Author(s):

Khaldoun Almhanna ◽

Maria Luisa Limon Miron ◽

David Wright ◽

Antonio Cubillo Gracian ◽

Richard A. Hubner ◽

...

Keyword(s):

Phase Ii ◽

Guanylyl Cyclase ◽

Phase Ii Study ◽

Gastroesophageal Junction ◽

Guanylyl Cyclase C ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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A phase II study of antibody-drug conjugate, TAK-264 (MLN0264) in previously treated patients with advanced or metastatic pancreatic adenocarcinoma expressing guanylyl cyclase C

Investigational New Drugs ◽

10.1007/s10637-017-0473-9 ◽

2017 ◽

Vol 35 (5) ◽

pp. 634-641 ◽

Cited By ~ 8

Author(s):

Khaldoun Almhanna ◽

David Wright ◽

Teresa Macarulla Mercade ◽

Jean-Luc Van Laethem ◽

Antonio Cubillo Gracian ◽

...

Keyword(s):

Pancreatic Adenocarcinoma ◽

Phase Ii ◽

Guanylyl Cyclase ◽

Phase Ii Study ◽

Guanylyl Cyclase C ◽

Antibody Drug Conjugate ◽

Metastatic Pancreatic Adenocarcinoma ◽

Previously Treated Patients ◽

Previously Treated ◽

Antibody Drug

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Abstract CT117: A phase II trial of TAK-264, a novel antibody-drug conjugate (ADC), in patients with pancreatic adenocarcinoma expressing guanylyl cyclase C (GCC)

10.1158/1538-7445.am2016-ct117 ◽

2016 ◽

Author(s):

Khaldoun Almhanna ◽

David Wright ◽

Teresa Macarulla Mercadé ◽

Jean-Luc Van Laethem ◽

Antonio Cubillo Gracian ◽

...

Keyword(s):

Pancreatic Adenocarcinoma ◽

Phase Ii ◽

Guanylyl Cyclase ◽

Phase Ii Trial ◽

Guanylyl Cyclase C ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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Abstract 3916: Relationship of guanylyl cyclase C (GCC) expression and efficacy of TAK-164, a GCC-targeted antibody-drug conjugate in a panel of 68 subcutaneous HuPrime colorectal cancer PDX models

10.1158/1538-7445.am2018-3916 ◽

2018 ◽

Cited By ~ 1

Author(s):

Erik M. Koenig ◽

Cong Li ◽

Huyuan Yang ◽

Andy Zhu ◽

Pooja Shah ◽

...

Keyword(s):

Colorectal Cancer ◽

Guanylyl Cyclase ◽

Guanylyl Cyclase C ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Relationship Of ◽

Pdx Models ◽

Antibody Drug

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Open-label, Multicenter, Phase II Study of RC48-ADC, a HER2-Targeting Antibody–Drug Conjugate, in Patients with Locally Advanced or Metastatic Urothelial Carcinoma

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-20-2488 ◽

2020 ◽

Vol 27 (1) ◽

pp. 43-51

Author(s):

Xinan Sheng ◽

Xieqiao Yan ◽

Lin Wang ◽

Yanxia Shi ◽

Xin Yao ◽

...

Keyword(s):

Urothelial Carcinoma ◽

Phase Ii ◽

Phase Ii Study ◽

Locally Advanced ◽

Antibody Drug Conjugate ◽

Open Label ◽

Drug Conjugate ◽

Multicenter Phase ◽

Metastatic Urothelial Carcinoma ◽

Antibody Drug

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Abstract PR12: MLN0264, an investigational, first-in-class antibody-drug conjugate (ADC) targeting guanylyl cyclase C (GCC), demonstrates antitumor activity alone and in combination with gemcitabine in human pancreatic cancer xenograft models expressing GCC.

10.1158/1535-7163.targ-13-pr12 ◽

2013 ◽

Cited By ~ 4

Author(s):

Julie Zhang ◽

Melissa Gallery ◽

Tim Wyant ◽

Brad Stringer ◽

Mark Manfredi ◽

...

Keyword(s):

Pancreatic Cancer ◽

Antitumor Activity ◽

Guanylyl Cyclase ◽

Human Pancreatic Cancer ◽

Guanylyl Cyclase C ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Xenograft Models ◽

Class Antibody ◽

Antibody Drug

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Phase I Study of the Investigational Anti-Guanylyl Cyclase C (GCC) Antibody-Drug Conjugate (ADC) Mln0264 in Adult Patients with Advanced Gastrointestinal Malignancies Expressing GCC

Annals of Oncology ◽

10.1093/annonc/mdu193.9 ◽

2014 ◽

Vol 25 ◽

pp. ii108 ◽

Cited By ~ 1

Author(s):

J.E. Faris ◽

C. Cruz ◽

K. Almhanna ◽

W. Messersmith ◽

J. Rodon ◽

...

Keyword(s):

Phase I ◽

Guanylyl Cyclase ◽

Phase I Study ◽

Adult Patients ◽

Guanylyl Cyclase C ◽

Antibody Drug Conjugate ◽

Gastrointestinal Malignancies ◽

Drug Conjugate ◽

Antibody Drug

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Anti-NaPi2b antibody–drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study

Annals of Oncology ◽

10.1093/annonc/mdy023 ◽

2018 ◽

Vol 29 (4) ◽

pp. 917-923 ◽

Cited By ~ 19

Author(s):

S. Banerjee ◽

A.M. Oza ◽

M.J. Birrer ◽

E.P. Hamilton ◽

J. Hasan ◽

...

Keyword(s):

Ovarian Cancer ◽

Phase Ii ◽

Liposomal Doxorubicin ◽

Phase Ii Study ◽

Pegylated Liposomal Doxorubicin ◽

Antibody Drug Conjugate ◽

Open Label ◽

Drug Conjugate ◽

Open Label Phase ◽

Antibody Drug

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A Phase II Study of Trastuzumab-DM1 (T-DM1), a Novel HER2 Antibody–Drug Conjugate, in HER2+ Metastatic Breast Cancer (MBC) Patients Previously Treated with Conventional Chemotherapy, Lapatinib and Trastuzumab.

10.1158/0008-5472.sabcs-09-5090 ◽

2009 ◽

Cited By ~ 23

Author(s):

I. Krop ◽

P. LoRusso ◽

K. Miller ◽

S. Modi ◽

D. Yardley ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Phase Ii ◽

Phase Ii Study ◽

Metastatic Breast ◽

Conventional Chemotherapy ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Previously Treated ◽

Antibody Drug

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Abstract 4649: Using pharmacokinetic/efficacy modeling to identify the optimal schedule for MLN0264, an anti- guanylyl cyclase C (GCC) antibody-drug conjugate, in a range of xenograft models

10.1158/1538-7445.am2014-4649 ◽

2014 ◽

Cited By ~ 1

Author(s):

Shu-Wen Teng ◽

Christopher Zopf ◽

Johnny Yang ◽

Brad Stringer ◽

Julie Zhang ◽

...

Keyword(s):

Guanylyl Cyclase ◽

Optimal Schedule ◽

Guanylyl Cyclase C ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Xenograft Models ◽

Antibody Drug

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Mln0264, an Investigational, First-In-Class Antibody-Drug Conjugate Targeting Guanylyl Cyclase C (Gcc): First-In-Human Study in Patients with Advanced Gastrointestinal Malignancies

Annals of Oncology ◽

10.1093/annonc/mdt202.30 ◽

2013 ◽

Vol 24 ◽

pp. iv36 ◽

Cited By ~ 2

Author(s):

Wells Messersmith ◽

Khaldoun Almhanna ◽

Jordi Rodon ◽

Cristina Cruz ◽

David Ryan ◽

...

Keyword(s):

Guanylyl Cyclase ◽

Human Study ◽

Guanylyl Cyclase C ◽

Antibody Drug Conjugate ◽

Gastrointestinal Malignancies ◽

Drug Conjugate ◽

Class Antibody ◽

Antibody Drug

Download Full-text