Acute Inhibition of Cardiac Monoamine Oxidase A after Tobacco Smoke Inhalation: Validation Study of [11C]Befloxatone in Rats Followed by a Positron Emission Tomography Application in Baboons

2005 ◽  
Vol 314 (1) ◽  
pp. 431-436 ◽  
Author(s):  
Héric Valette ◽  
Michel Bottlaender ◽  
Frédéric Dollé ◽  
Christine Coulon ◽  
Michèle Ottaviani ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Monoamine Oxidase ◽  
Tobacco Smoke ◽  
Validation Study ◽  
Monoamine Oxidase A ◽  
Smoke Inhalation ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Positron Emission Tomography Quantification of [11C]-Harmine Binding to Monoamine Oxidase-A in the Human Brain

2005 ◽  
Vol 26 (3) ◽  
pp. 330-344 ◽  
Author(s):  
Nathalie Ginovart ◽  
Jeffrey H Meyer ◽  
Anahita Boovariwala ◽  
Doug Hussey ◽  
Eugenii A Rabiner ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Monoamine Oxidase ◽  
Human Brain ◽  
Monoamine Oxidase A ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Greater Monoamine Oxidase A Binding in Perimenopausal Age as Measured With Carbon 11–Labeled Harmine Positron Emission Tomography

2014 ◽  
Vol 71 (8) ◽  
pp. 873 ◽  
Author(s):  
Paraskevi Vivien Rekkas ◽  
Alan A. Wilson ◽  
Vivian Wai Han Lee ◽  
Priyanga Yogalingam ◽  
Julia Sacher ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Monoamine Oxidase ◽  
Monoamine Oxidase A ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Dynamic, Adaptive Changes in MAO-A Binding after Alterations in Substrate Availability: An in vivo [11C]-Harmine Positron Emission Tomography Study

2011 ◽  
Vol 32 (3) ◽  
pp. 443-446 ◽  
Author(s):  
Julia Sacher ◽  
Eugenii A Rabiner ◽  
Michael Clark ◽  
Pablo Rusjan ◽  
Alexandra Soliman ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Monoamine Oxidase ◽  
Monoamine Oxidase A ◽  
Emission Tomography ◽  
Tryptophan Depletion ◽  
Major Depressive ◽  
Positron Emission ◽  
Mao A ◽  
Adaptive Role

Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [11C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A VT, an index of MAO-A density, was decreased (mean: 14%±9%) following tryptophan depletion in prefrontal cortex ( P<0.031), and elevated (mean: 17%±11%) in striatum following carbidopa—levodopa administration ( P<0.007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels.

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