scholarly journals Lower Monoamine Oxidase-A Total Distribution Volume in Impulsive and Violent Male Offenders with Antisocial Personality Disorder and High Psychopathic Traits: An [11C] Harmine Positron Emission Tomography Study

2015 ◽  
Vol 40 (11) ◽  
pp. 2596-2603 ◽  
Author(s):  
Nathan J Kolla ◽  
Brittany Matthews ◽  
Alan A Wilson ◽  
Sylvain Houle ◽  
R Michael Bagby ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Personality Disorder ◽  
Monoamine Oxidase ◽  
Antisocial Personality Disorder ◽  
Distribution Volume ◽  
Monoamine Oxidase A ◽  
Emission Tomography ◽  
Antisocial Personality ◽  
Male Offenders ◽  
Positron Emission

scholarly journals Positron Emission Tomography Quantification of [11C]-Harmine Binding to Monoamine Oxidase-A in the Human Brain

2005 ◽  
Vol 26 (3) ◽  
pp. 330-344 ◽  
Author(s):  
Nathalie Ginovart ◽  
Jeffrey H Meyer ◽  
Anahita Boovariwala ◽  
Doug Hussey ◽  
Eugenii A Rabiner ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Monoamine Oxidase ◽  
Human Brain ◽  
Monoamine Oxidase A ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Greater Monoamine Oxidase A Binding in Perimenopausal Age as Measured With Carbon 11–Labeled Harmine Positron Emission Tomography

2014 ◽  
Vol 71 (8) ◽  
pp. 873 ◽  
Author(s):  
Paraskevi Vivien Rekkas ◽  
Alan A. Wilson ◽  
Vivian Wai Han Lee ◽  
Priyanga Yogalingam ◽  
Julia Sacher ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Monoamine Oxidase ◽  
Monoamine Oxidase A ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Lower amygdala fatty acid amide hydrolase in violent offenders with antisocial personality disorder: an [11C]CURB positron emission tomography study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nathan J. Kolla ◽  
Isabelle Boileau ◽  
Karolina Karas ◽  
Jeremy J. Watts ◽  
Pablo Rusjan ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Antisocial Personality Disorder ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Reactive Aggression ◽  
Emission Tomography ◽  
Antisocial Personality ◽  
Positron Emission ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

AbstractAntisocial personality disorder (ASPD) imposes a high societal burden given the repetitive reactive aggression that affected individuals perpetrate. Since the brain endocannabinoid system (ECS) has been implicated in ASPD and aggressive behavior, we utilized [11C]CURB positron emission tomography to investigate fatty acid amide hydrolase (FAAH), an enzyme of the ECS that degrades anandamide, in 16 individuals with ASPD and 16 control participants. We hypothesized that FAAH density would be lower in the amygdala for several reasons. First, decreased FAAH expression is associated with increased cannabinoid receptor 1 stimulation, which may be responsible for amygdala hyper-reactivity in reactive aggression. Second, the amygdala is the seat of the neural circuit mediating reactive aggression. Third, other PET studies of externalizing populations show reduced brain FAAH density. Conversely, we hypothesized that FAAH expression would be greater in the orbitofrontal cortex. Consistent with our hypothesis, we found that amygdala FAAH density was lower in the amygdala of ASPD (p = 0.013). Cerebellar and striatal FAAH expression were inversely related with impulsivity (cerebellum: r = −0.60, p = 0.017; dorsal caudate: r = −0.58, p = 0.023; dorsal putamen: r = −0.55, p = 0.034), while cerebellar FAAH density was also negatively associated with assaultive aggression (r = −0.54, p = 0.035). ASPD presents high levels of disruptive behavior with few, if any, efficacious treatment options. Novel therapeutics that increase FAAH brain levels in a region-specific manner could hold promise for attenuating certain symptom clusters of ASPD, although our results require replication.

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