A Comparison between the Cardiovascular Actions of Urocortin 1 and Urocortin 2 (Stresscopin-Related Peptide) in Conscious Rats

2007 ◽  
Vol 321 (1) ◽  
pp. 221-226 ◽  
Author(s):  
S. M. Gardiner ◽  
J. E. March ◽  
P. A. Kemp ◽  
T. Bennett
1990 ◽  
Vol 99 (4) ◽  
pp. 830-834 ◽  
Author(s):  
Sheila M. Gardiner ◽  
Alix M. Compton ◽  
Terence Bennett ◽  
Philip A. Kemp ◽  
Ursula Ney

1991 ◽  
Vol 260 (6) ◽  
pp. R1188-R1193 ◽  
Author(s):  
P. E. Pergola ◽  
R. H. Alper

Intracerebroventricular administration of serotonin (5-HT) to conscious rats increases mean arterial pressure (MAP) and decreases heart rate. To determine the mechanisms involved, 5-HT (2.5 micrograms) was injected intracerebroventricularly into conscious rats pretreated with various neurotransmitter and hormone antagonists. The selective 5-HT2 antagonist LY 53857 abolished the increase in MAP and the bradycardia elicited by 5-HT. The increase in MAP produced by 5-HT was potentiated by chlorisondamine (a ganglionic antagonist), unaffected by prazosin (an alpha 1-antagonist) or a vasopressin V1 antagonist alone, but eliminated by the combined pretreatment with prazosin plus the vasopressin antagonist. In contrast, the bradycardia was eliminated by either the vasopressin V1 antagonist or chlorisondamine. In conclusion, 5-HT injected into the lateral cerebral ventricle of conscious rats induces sympathoexcitation and the release of vasopressin, which results in an increase in MAP; 5-HT also elicits a bradycardia mediated through an interaction of the autonomic nervous system with circulating vasopressin.


1987 ◽  
Vol 19 (5-6) ◽  
pp. 307-312 ◽  
Author(s):  
Rodney W. Lappe ◽  
Mark J. Slivjak ◽  
Joy A. Todt ◽  
Robert L. Wendt

Diabetes ◽  
1990 ◽  
Vol 39 (2) ◽  
pp. 168-174 ◽  
Author(s):  
A. Yamaguchi ◽  
T. Chiba ◽  
T. Morishita ◽  
A. Nakamura ◽  
T. Inui ◽  
...  

2000 ◽  
Vol 50 (2) ◽  
pp. 243-248 ◽  
Author(s):  
Setsuko Kanai ◽  
Masao Masuda ◽  
Shinji Suzuki ◽  
Minoru Ohta ◽  
Yuki Yoshida ◽  
...  

2005 ◽  
Vol 125 (1-3) ◽  
pp. 55-59 ◽  
Author(s):  
Shuntaro Kagiyama ◽  
Masayo Fukuhara ◽  
Kiyoshi Matsumura ◽  
Yingzi Lin ◽  
Koji Fujii ◽  
...  

2013 ◽  
Vol 186 ◽  
pp. 7-11 ◽  
Author(s):  
Ri Jin ◽  
Mei-Zi Li ◽  
Yan-Hua Bing ◽  
Ri-Long Piao ◽  
Ying-Jun Li ◽  
...  

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