Targeting the Myofibroblast Genetic Switch: Inhibitors of Myocardin-Related Transcription Factor/Serum Response Factor–Regulated Gene Transcription Prevent Fibrosis in a Murine Model of Skin Injury

Faculty Opinions recommendation of Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718340412.793516930 ◽

2016 ◽

Author(s):

Giulio Gabbiani ◽

Boris Hinz

Keyword(s):

Transcription Factor ◽

Gene Transcription ◽

Murine Model ◽

Serum Response Factor ◽

Response Factor ◽

Skin Injury ◽

Genetic Switch ◽

5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b01772 ◽

2019 ◽

Vol 62 (9) ◽

pp. 4350-4369 ◽

Cited By ~ 10

Author(s):

Dylan J. Kahl ◽

Kim M. Hutchings ◽

Erika Mathes Lisabeth ◽

Andrew J. Haak ◽

Jeffrey R. Leipprandt ◽

...

Keyword(s):

Transcription Factor ◽

Gene Transcription ◽

Serum Response Factor ◽

Response Factor ◽

New Class ◽

Antifibrotic Agents ◽

Olfactomedin 2 Regulates Smooth Muscle Phenotypic Modulation and Vascular Remodeling Through Mediating Runt-Related Transcription Factor 2 Binding to Serum Response Factor

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.116.308606 ◽

2017 ◽

Vol 37 (3) ◽

pp. 446-454 ◽

Cited By ~ 14

Author(s):

Ning Shi ◽

Chen-Xiao Li ◽

Xiao-Bing Cui ◽

Stanislav I. Tomarev ◽

Shi-You Chen

Keyword(s):

Transcription Factor ◽

Smooth Muscle ◽

Vascular Remodeling ◽

Serum Response Factor ◽

Response Factor ◽

Phenotypic Modulation ◽

Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin‐related transcription factor‐B, negatively regulates dendritic complexity in cortical neurons

Journal of Neurochemistry ◽

10.1111/jnc.15122 ◽

2020 ◽

Author(s):

Yuta Ishibashi ◽

Shizuku Shoji ◽

Daisuke Ihara ◽

Yukimi Kubo ◽

Takuro Tanaka ◽

...

Keyword(s):

Transcription Factor ◽

Cortical Neurons ◽

Serum Response Factor ◽

Mouse Serum ◽

Response Factor ◽

Factor B ◽

Dendritic Complexity ◽

A myocardin-related transcription factor regulates activity of serum response factor in Drosophila

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.0405085101 ◽

2004 ◽

Vol 101 (34) ◽

pp. 12567-12572 ◽

Cited By ~ 53

Author(s):

Z. Han ◽

X. Li ◽

J. Wu ◽

E. N. Olson

Keyword(s):

Transcription Factor ◽

Serum Response Factor ◽

Response Factor ◽

Myocardin-Related Transcription Factor and Serum Response Factor Regulate Cilium Resorption and Ciliogenesis by Both Transcriptional and Local Mechanisms

SSRN Electronic Journal ◽

10.2139/ssrn.3661769 ◽

2020 ◽

Author(s):

Pam Speight ◽

Mattew Rozycki ◽

Katalin Szaszi ◽

Shruthi Venugopal ◽

Michael Kofler ◽

...

Keyword(s):

Transcription Factor ◽

Serum Response Factor ◽

Response Factor ◽

Downregulating the Myocardin-related transcription factor/ Serum response factor (MRTF/SRF) pathway is a novel therapeutic approach to prevent post-surgical fibrosis in glaucoma

Acta Ophthalmologica ◽

10.1111/j.1755-3768.2015.0500 ◽

2015 ◽

Vol 93 ◽

pp. n/a-n/a ◽

Cited By ~ 1

Author(s):

C. Yu-Wai-Man ◽

R. Treisman ◽

P.T. Khaw ◽

M. Bailly

Keyword(s):

Transcription Factor ◽

Therapeutic Approach ◽

Serum Response Factor ◽

Response Factor ◽

Serum Response ◽

Novel Therapeutic

Age-related reductions in expression of serum response factor and myocardin-related transcription factor A in mouse skeletal muscles

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ◽

10.1016/j.bbadis.2008.03.008 ◽

2008 ◽

Vol 1782 (7-8) ◽

pp. 453-461 ◽

Cited By ~ 35

Author(s):

Kunihiro Sakuma ◽

Mai Akiho ◽

Hiroyuki Nakashima ◽

Hiroshi Akima ◽

Masahiro Yasuhara

Keyword(s):

Transcription Factor ◽

Skeletal Muscles ◽

Serum Response Factor ◽

Response Factor ◽

Age Related ◽

Prostaglandin E2Inhibits α-Smooth Muscle Actin Transcription during Myofibroblast Differentiation via Distinct Mechanisms of Modulation of Serum Response Factor and Myocardin-related Transcription Factor-A

Journal of Biological Chemistry ◽

10.1074/jbc.m114.558130 ◽

2014 ◽

Vol 289 (24) ◽

pp. 17151-17162 ◽

Cited By ~ 49

Author(s):

Loka R. K. Penke ◽

Steven K. Huang ◽

Eric S. White ◽

Marc Peters-Golden

Keyword(s):

Transcription Factor ◽

Smooth Muscle ◽

Serum Response Factor ◽

Smooth Muscle Actin ◽

Myofibroblast Differentiation ◽

Response Factor ◽

Muscle Actin ◽

Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms

iScience ◽

10.1016/j.isci.2021.102739 ◽

2021 ◽

pp. 102739

Author(s):

Pam Speight ◽

Matthew Rozycki ◽

Shruthi Venugopal ◽

Katalin Szászi ◽

Michael Kofler ◽

...

Keyword(s):

Transcription Factor ◽

Serum Response Factor ◽

Response Factor ◽