Relative Opioid Efficacy Is Determined by the Complements of the G Protein-Coupled Receptor Desensitization Machinery

2004 ◽  
Vol 66 (1) ◽  
pp. 106-112 ◽  
Author(s):  
L. M. Bohn ◽  
L. A. Dykstra ◽  
R. J. Lefkowitz ◽  
M. G. Caron ◽  
L. S. Barak
Keyword(s):  
G Protein ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
Opioid Efficacy ◽  
G Protein Coupled

scholarly journals Histamine H2 Receptor Desensitization: Involvement of a Select Array of G Protein-Coupled Receptor Kinases

2001 ◽  
Vol 60 (5) ◽  
pp. 1049-1056 ◽  
Author(s):  
Carina Shayo ◽  
Natalia Fernandez ◽  
Bibiana Lemos Legnazzi ◽  
Federico Monczor ◽  
Alejandro Mladovan ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

Molecular mechanisms of G protein-coupled receptor desensitization and resensitization

Life Sciences ◽  
1998 ◽  
Vol 62 (17-18) ◽  
pp. 1561-1565 ◽  
Author(s):  
Stephen S.G. Ferguson ◽  
Jie Zhang ◽  
Larry S. Barakt ◽  
Marc G. Caron
Keyword(s):  
G Protein ◽  
Molecular Mechanisms ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals ARF6: a newly appreciated player in G protein-coupled receptor desensitization

FEBS Letters ◽  
2002 ◽  
Vol 521 (1-3) ◽  
pp. 3-8 ◽  
Author(s):  
Mary Hunzicker-Dunn ◽  
Vsevolod V. Gurevich ◽  
James E. Casanova ◽  
Sutapa Mukherjee
Keyword(s):  
G Protein ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

β-Arrestins: Multifunctional Cellular Mediators

Physiology ◽  
2008 ◽  
Vol 23 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Liza Barki-Harrington ◽  
Howard A. Rockman
Keyword(s):  
G Protein ◽  
Signaling Proteins ◽  
Receptor Desensitization ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
Cellular Mediators ◽  
The Many ◽  
G Protein Coupled

Initially thought to play a role only in G-protein-coupled receptor desensitization, β-arrestins are ascribed with new roles such as scaffolding and signaling proteins by their own right. This review explores the many functions of β-arrestins, with an emphasis on their recently identified role as regulators of receptor signaling.

Pleiotropic Role for GRKs and b-Arrestins in Receptor Regulation

Physiology ◽  
1997 ◽  
Vol 12 (4) ◽  
pp. 145-152 ◽  
Author(s):  
SSG Ferguson ◽  
J Zhang ◽  
LS Barak ◽  
MG Caron
Keyword(s):  
Angiotensin Ii ◽  
G Protein ◽  
Intracellular Trafficking ◽  
Coated Vesicle ◽  
Receptor Regulation ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Trafficking Molecules ◽  
G Protein Coupled

G protein-coupled receptor kinases and arrestin proteins are well-characterized mediators of agonist-dependent G protein-coupled receptor desensitization. These proteins are now shown to play a dual role in receptor regulation by mediating both receptor uncoupling and sequestration, a process important for receptor resensitization. b-Arrestins bound to phosporylated b2-adrenergic and angiotensin II type 1A receptors act as intracellular trafficking molecules specifically targeting these receptors for dynamin-dependent clathrin-coated vesicle-mediated sequestration.

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