An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover

Science ◽  
1987 ◽  
Vol 238 (4827) ◽  
pp. 672-675 ◽  
Author(s):  
A Ashkenazi ◽  
J. Winslow ◽  
E. Peralta ◽  
G. Peterson ◽  
M. Schimerlik ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Muscarinic Receptor ◽  
Receptor Subtype ◽  
Muscarinic Receptor Subtype ◽  
Phosphoinositide Turnover ◽  
M2 Muscarinic Receptor

Does mammalian heart contain only the m2 muscarinic receptor subtype?

Life Sciences ◽  
1997 ◽  
Vol 60 (13-14) ◽  
pp. 1023-1029 ◽  
Author(s):  
Virendra K. Sharma ◽  
Henry M. Colecraft ◽  
Lisa E. Rubin ◽  
Shey-Shing Sheu
Keyword(s):  
Muscarinic Receptor ◽  
Receptor Subtype ◽  
Muscarinic Receptor Subtype ◽  
Mammalian Heart ◽  
M2 Muscarinic Receptor

The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles

2008 ◽  
Vol 378 (1) ◽  
pp. 103-116 ◽  
Author(s):  
Jaromir Myslivecek ◽  
Martin Klein ◽  
Martina Novakova ◽  
Jan Ricny
Keyword(s):  
Muscarinic Receptor ◽  
Rat Heart ◽  
Receptor Subtype ◽  
Muscarinic Receptor Subtype ◽  
M2 Muscarinic Receptor ◽  
Heart Atria

Different regulatory patterns of M1 and M2 muscarinic receptor subtype RNA in SH-SY5Y human neuroblastoma induced by phorbol ester or DMSO

1993 ◽  
Vol 149 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Ahmet Koman ◽  
Sylvie Cazaubon ◽  
Abdu Adem ◽  
Pierre-Olivier Couraud ◽  
A.Donny Strosberg
Keyword(s):  
Muscarinic Receptor ◽  
Phorbol Ester ◽  
Receptor Subtype ◽  
Human Neuroblastoma ◽  
Muscarinic Receptor Subtype ◽  
M2 Muscarinic Receptor

Inhibition of cyclic AMP formation in N1E-115 neuroblastoma cells is mediated by a non-cardiac M2 muscarinic receptor subtype

1989 ◽  
Vol 493 (2) ◽  
pp. 320-325 ◽  
Author(s):  
Wanida Surichamorn ◽  
Carla L. Amrhein ◽  
Carlos Forray ◽  
Esam E. El-Fakahany
Keyword(s):  
Cyclic Amp ◽  
Muscarinic Receptor ◽  
Neuroblastoma Cells ◽  
Receptor Subtype ◽  
Muscarinic Receptor Subtype ◽  
M2 Muscarinic Receptor

scholarly journals Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice

2013 ◽  
Vol 42 (6) ◽  
pp. 1677-1688 ◽  
Author(s):  
Loes E.M. Kistemaker ◽  
I.S.T. Bos ◽  
Machteld N. Hylkema ◽  
Martijn C. Nawijn ◽  
Pieter S. Hiemstra ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Cigarette Smoke ◽  
Receptor Subtype ◽  
Muscarinic Receptor Subtype ◽  
Specific Effects

Altered muscarinic receptor subtype expression and functional responses in cyclophosphamide induced cystitis in rats

2005 ◽  
Vol 122 (1-2) ◽  
pp. 9-20 ◽  
Author(s):  
D. Giglio ◽  
A.T. Ryberg ◽  
K. To ◽  
D.S. Delbro ◽  
G. Tobin
Keyword(s):  
Muscarinic Receptor ◽  
Receptor Subtype ◽  
Functional Responses ◽  
Muscarinic Receptor Subtype

Basenji-greyhound dog: increased m2 muscarinic receptor expression in trachealis muscle

1995 ◽  
Vol 268 (6) ◽  
pp. L935-L940 ◽  
Author(s):  
C. W. Emala ◽  
A. Aryana ◽  
M. A. Levine ◽  
R. P. Yasuda ◽  
S. A. Satkus ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Adenylyl Cyclase ◽  
Muscarinic Receptor ◽  
Airway Smooth Muscle ◽  
Muscle Relaxation ◽  
Receptor Expression ◽  
Smooth Muscle Relaxation ◽  
Muscarinic Agonists ◽  
M2 Muscarinic Receptor ◽  
Muscarinic M2 Receptors

Airway smooth muscle from asthmatic humans and from the Basenji-greyhound dog (BG) dog is hyporesponsive to beta-adrenergic agonist stimulation. Because adenylyl cyclase is under dual regulation in airway smooth muscle, we compared muscarinic receptor-coupled inhibition of adenylyl cyclase in airway smooth muscle from BG and mongrel dogs. Inhibition of forskolin-stimulated adenylyl cyclase activity by the muscarinic M2 agonist oxotremorine was greater in airway smooth muscle membranes from BG compared with mongrel controls. Quantitative immunoprecipitation studies showed increased numbers of m2 but not m3 muscarinic receptors in the BG airway smooth muscle. The enhanced ability of muscarinic agonists to inhibit adenylyl cyclase in BG airway smooth muscle may be due to the greater numbers of muscarinic m2 receptors, which may account in part for impaired airway smooth muscle relaxation in the BG model of airway hyperresponsiveness.

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