scholarly journals Phase separation of signaling molecules promotes T cell receptor signal transduction

Science ◽  
2016 ◽  
Vol 352 (6285) ◽  
pp. 595-599 ◽  
Author(s):  
Xiaolei Su ◽  
Jonathon A. Ditlev ◽  
Enfu Hui ◽  
Wenmin Xing ◽  
Sudeep Banjade ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Phase Separation ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Signaling Molecules ◽  
Receptor Signal

Abstract A087: Phase separation of signaling molecules promotes T cell receptor signal transduction

2016 ◽  
Author(s):  
Xiaolei Su ◽  
Jon Ditlev ◽  
Enfu Hui ◽  
Sudeep Banjade ◽  
Julia Okrut ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Phase Separation ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Signaling Molecules ◽  
Receptor Signal

scholarly journals A therapeutic anti-CD4 monoclonal antibody inhibits T cell receptor signal transduction in mouse autoimmune cardiomyopathy

2007 ◽  
Vol 120 (15) ◽  
pp. 1319-1325 ◽  
Author(s):  
Zhao-hui WANG ◽  
Yu-hua LIAO ◽  
Jing YUAN ◽  
Li ZHANG ◽  
Min WANG ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Monoclonal Antibody ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Signal

scholarly journals Hypoxia inducible factor 1  regulates T cell receptor signal transduction

2005 ◽  
Vol 102 (47) ◽  
pp. 17071-17076 ◽  
Author(s):  
A. K. Neumann ◽  
J. Yang ◽  
M. P. Biju ◽  
S. K. Joseph ◽  
R. S. Johnson ◽  
...  
Keyword(s):  
Signal Transduction ◽  
T Cell ◽  
T Cell Receptor ◽  
Hypoxia Inducible Factor ◽  
Cell Receptor ◽  
Hypoxia Inducible Factor 1 ◽  
Receptor Signal

T cell receptor signal transduction: affinity, force and conformational change

2018 ◽  
Vol 19 ◽  
pp. 43-50 ◽  
Author(s):  
Duane Moogk ◽  
Aswin Natarajan ◽  
Michelle Krogsgaard
Keyword(s):  
Signal Transduction ◽  
T Cell ◽  
Conformational Change ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Signal

scholarly journals Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction

1999 ◽  
Vol 190 (10) ◽  
pp. 1517-1526 ◽  
Author(s):  
Rémy Bosselut ◽  
Weiguo Zhang ◽  
Jennifer M. Ashe ◽  
Jeffrey L. Kopacz ◽  
Lawrence E. Samelson ◽  
...  
Keyword(s):  
Signal Transduction ◽  
T Cell ◽  
T Cell Receptor ◽  
Protein Tyrosine Kinase ◽  
Adaptor Protein ◽  
Cell Receptor ◽  
Downstream Signaling ◽  
Cysteine Motif ◽  
Receptor Signal ◽  
Tcr Signal Transduction

Linker for activation of T cells (LAT) is an adaptor protein whose tyrosine phosphorylation is critical for transduction of the T cell receptor (TCR) signal. LAT phosphorylation is accomplished by the protein tyrosine kinase ZAP-70, but it is not at all clear how LAT (which is not associated with the TCR) encounters ZAP-70 (which is bound to the TCR). Here we show that LAT associates with surface CD4 and CD8 coreceptors and that its association is promoted by the same coreceptor cysteine motif that mediates Lck binding. In fact, LAT competes with Lck for binding to individual coreceptor molecules but differs from Lck in its preferential association with CD8 rather than CD4 in CD4+CD8+ thymocytes. Importantly, as a consequence of LAT association with surface coreceptors, coengagement of the TCR with surface coreceptors induces LAT phosphorylation and the specific recruitment of downstream signaling mediators to coreceptor-associated LAT molecules. These results point to a new function for CD4 and CD8 coreceptors in TCR signal transduction, namely to promote LAT phosphorylation by ZAP-70 by recruiting LAT to major histocompatibility complex–engaged TCR complexes.

scholarly journals SH2 Domain Function Is Essential for the Role of the Lck Tyrosine Kinase in T Cell Receptor Signal Transduction

1996 ◽  
Vol 271 (17) ◽  
pp. 9976-9981 ◽  
Author(s):  
David B. Straus ◽  
Andrew C. Chan ◽  
Barbara Patai ◽  
Arthur Weiss
Keyword(s):  
Signal Transduction ◽  
T Cell ◽  
Tyrosine Kinase ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Sh2 Domain ◽  
Receptor Signal
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