scholarly journals Saltational evolution of the heterotrimeric G protein signaling mechanisms in the plant kingdom

2016 ◽  
Vol 9 (446) ◽  
pp. ra93-ra93 ◽  
Author(s):  
Daisuke Urano ◽  
Natsumi Maruta ◽  
Yuri Trusov ◽  
Richard Stoian ◽  
Qingyu Wu ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Heterotrimeric G Protein ◽  
Plant Kingdom ◽  
Signaling Mechanisms ◽  
Saltational Evolution ◽  
Heterotrimeric G Protein Signaling

scholarly journals Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans

2007 ◽  
Vol 179 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Claudia Couwenbergs ◽  
Jean-Claude Labbé ◽  
Morgan Goulding ◽  
Thomas Marty ◽  
Bruce Bowerman ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Dynein Light Chain ◽  
Loss Of Function ◽  
Functional Link ◽  
Heterotrimeric G Protein ◽  
Spindle Positioning ◽  
C Elegans ◽  
Heterotrimeric G Protein Signaling

Proper orientation and positioning of the mitotic spindle is essential for the correct segregation of fate determinants during asymmetric cell division. Although heterotrimeric G proteins and their regulators are essential for spindle positioning in many cell types, their mechanism of action remains unclear. In this study, we show that dyrb-1, which encodes a dynein light chain, provides a functional link between heterotrimeric G protein signaling and dynein activity during spindle positioning in Caenorhabditis elegans. Embryos depleted of dyrb-1 display phenotypes similar to a weak loss of function of dynein activity, indicating that DYRB-1 is a positive regulator of dynein. We find that the depletion of dyrb-1 enhances the spindle positioning defect of weak loss of function alleles of two regulators of G protein signaling, LIN-5 and GPR-1/2, and that DYRB-1 physically associates with these two proteins. These results indicate that dynein activity functions with regulators of G protein signaling to regulate common downstream effectors during spindle positioning in the early C. elegans embryo.

scholarly journals Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update

2017 ◽  
Vol 98 (2) ◽  
pp. 190-197 ◽  
Author(s):  
Issam H Abu-Taha ◽  
Jordi Heijman ◽  
Yuxi Feng ◽  
Christiane Vettel ◽  
Dobromir Dobrev ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Heterotrimeric G Protein ◽  
Heterotrimeric G Protein Signaling
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