A New Concept of Electronic Text Based on Semantic Coding System for Machine Translation

In the field of machine translation of texts, the ambiguity in both lexical (dictionary) and structural aspects is still one of the difficult problems. Researchers in this field use different approaches, the most important of which is machine learning in its various types. The goal of the approach that we propose in this article is to define a new concept of electronic text, which makes the electronic text free from any lexical or structural ambiguity. We used a semantic coding system that relies on attaching the original electronic text (via the text editor interface) with the meanings intended by the author. The author defines the meaning desired for each word that can be a source of ambiguity. The proposed approach in this article can be used with any type of electronic text (text processing applications, web pages, email text, etc.). Thanks to the approach that we propose and through the experiments that we have conducted using it, we can obtain a very high accuracy rate. We can say that the problem of lexical and structural ambiguity can be completely solved. With this new concept of electronic text, the text file contains not only the text but also with it the true sense of the exact meaning intended by the writer in the form of symbols. These semantic symbols are used during machine translation to obtain a translated text completely free of any lexical and structural ambiguity.

Compositional, Structural, and Kinetic Aspects of Lipid Digestion and Bioavailability: In Vitro, In Vivo, and Modeling Approaches

Lipid digestion and bioavailability are usually investigated separately, using different approaches (in vitro, modeling, in vivo). However, a few inclusive studies show that their kinetics are closely linked. Lipid bioavailability kinetics is likely involved in the development and evolution of several diseases, so lipid digestion kinetics could be involved as well and can be modulated by food design or combination. To illustrate this possibility, the compositional and structural aspects of lipid digestion kinetics, as investigated using in vitro and modeling approaches, are presented first. Then, in vivo and mixed approaches enabling the study of both kinetics are reviewed and discussed. Finally, disparate modeling approaches are introduced, and a unifying modeling scheme is proposed, opening new perspectives for understanding the role and interactions of various factors (chemical, physical, and biological) involved in lipid metabolism. Expected final online publication date for the Annual Review of Food Science and Technology, Volume 13 is March 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Structural Aspects of LIMK Regulation and Pharmacology

Malfunction of the actin cytoskeleton is linked to numerous human diseases including neurological disorders and cancer. LIMK1 (LIM domain kinase 1) and its paralogue LIMK2 are two closely related kinases that control actin cytoskeleton dynamics. Consequently, they are potential therapeutic targets for the treatment of such diseases. In the present review, we describe the LIMK conformational space and its dependence on ligand binding. Furthermore, we explain the unique catalytic mechanism of the kinase, shedding light on substrate recognition and how LIMK activity is regulated. The structural features are evaluated for implications on the drug discovery process. Finally, potential future directions for targeting LIMKs pharmacologically, also beyond just inhibiting the kinase domain, are discussed.

Better Health Communication During the Life Cycle Contributes to Better Health Literacy

Health literacy (HL) is about acquiring competences, confidence, and motivation to take action in health improvement. Health communication is key in promoting HL. Information leaflets are a tool that grants autonomy, thereby empowering self-management of health. Qualitative and content analysis of two original leaflets was made by a group of medical doctors, targeting pregnant women and the elderly, who represent different stages of the life cycle. The content was written in an assertive, clear, and positive language, and was adjusted to the target public. A question-answer system was used, making it easier for the reader to gather specific information. Structural aspects underlying both leaflets were similar. Health leaflets are widely used for the proper transmission of information. It is therefore essential that they are appropriate to the recipients' HL throughout the life cycle. The critical and systematised analysis of their information content contributes to quality assurance, leading to better HL and healthcare in general.

As Unidades de Paisagem no município de Areado, sul de Minas Gerais: uma proposta de estudo ambiental integrado a partir da concepção geossistêmica

A paisagem se apresenta como uma unidade de investigação de significativa importância no que tange aos estudos ambientais. Dessa forma, o agrupamento de suas variáveis em unidades pode avultar como estratégia metodológica para compreensão das estruturas e dinâmicas espaciais, e nesse sentido a concepção geossistêmica, aqui trabalhada segundo os pressupostos russo-soviéticos, fornece o aporte teórico-metodológico adequado. Desse modo, o presente trabalho tem por objetivo interpretar, classificar, cartografar e discutir os aspectos estruturais da paisagem no município de Areado (sul de Minas Gerais) a partir da abordagem geossistêmica. Para tal, foi necessário por intermédio do Sistema de Informações Geográficas (SIG) reunir um banco de dados com variáveis chave e complementares, que se referem às seguintes variáveis: solo, geologia, unidades geomorfológicas, uso e cobertura da terra. Tais variáveis foram individualizadas em grupos de fácies segundo a proposta de hierarquização dos geossistemas de Sochava (1977,1978). Dessa forma, obteve-se 14 tipologias geossistêmicas que representam em grande parte a estrutura da paisagem, reunidos em duas classes de fácies, que retratam as principais organizações geomorfológicas regionais definidas pelas superfícies altimontanas e intermontanas. Os resultados obtidos podem subsidiar diretamente programas de planejamento territorial e governança do patrimônio ambiental, garantindo a manutenção dos serviços ambientais existentes e orientando da forma mais parcimoniosa possível os usos econômicos do espaço. The Landscape Units in the municipality of Areado, south of Minas Gerais: a proposal for an integrated environmental study from the geosystemic conception A B S T R A C TThe landscape presentes itself as an investigation unity of significant importance with regard to environmental studies. Thus, the grouping of its variables into units can enlarge as a methodological strategy towards the comprehension of the spacial structures and dynamics, and in this sense the geosystemic conception, considereded here according to the Russian-Soviet assumptions, provides the appropriate theoretical and methodological support. Thereby, this present research aims to interpret, classify, map, discuss the structural aspects of the landscape in the municipality of Areado (south of Minas Gerais) from the geosystemic approach. For that purpose, it was necessary through the Geographic Information System (GIS) to gather a database with key and complementary variables, which refer to the following variables: soil, geology, geomorphological units, land use cover. Such variables were individualized in groups of facies according to the geosystems hierarchization proposal of Sochava (1977, 1978). Thus, fourteen geosystemic typologies were obtained, which largely represent the landscape structure, gathered in two classes of facies, that retract the main regional geomorphological organizations defined by the altimontana and intermontana surfaces. The obtained results may directly subsidize programs of territorial planning and governance of environmental heritage, ensuring the maintenance of existing environmental services and guiding in the most parsimonious way possible the economic uses of space.Key words: landscape, geosystem, environmental analysis, management, planning.