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Published By American Association For The Advancement Of Science (Aaas)

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Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression

2022 ◽  
Vol 15 (716) ◽  
Author(s):  
Kazuhiro Nishiyama ◽  
Akiyuki Nishimura ◽  
Kakeru Shimoda ◽  
Tomohiro Tanaka ◽  
Yuri Kato ◽  
...  
Keyword(s):  
Purinergic Receptor ◽  
Cysteine Modification

Cysteine modification of the purinergic receptor P2Y 6 R promotes internalization and degradation and limits colitis progression.

Retinoic acid for gut health

2022 ◽  
Vol 15 (716) ◽  
Author(s):  
Annalisa M. VanHook
Keyword(s):  
Retinoic Acid ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Gut Health

Commensal-derived retinoic acid protects mice against infection by priming the innate defenses of intestinal epithelial cells.

Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis

2022 ◽  
Vol 15 (716) ◽  
Author(s):  
Bonah Kim ◽  
Hee Young Kim ◽  
Bo Ruem Yoon ◽  
Jina Yeo ◽  
Ji In Jung ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Monocytes And Macrophages

Zinc metabolically reprograms monocytes and macrophages to promote inflammation in rheumatoid arthritis.

The PIKK-AKT connection in the DNA damage response

2022 ◽  
Vol 15 (715) ◽  
Author(s):  
Sejeong Shin ◽  
Katherine A. Walker ◽  
Sang-Oh Yoon
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Damage Response

DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway

2022 ◽  
Vol 15 (715) ◽  
Author(s):  
Liu Liu ◽  
Xiaoming Dai ◽  
Shasha Yin ◽  
Pengda Liu ◽  
Elizabeth G. Hill ◽  
...  
Keyword(s):  
Dna Damage

ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3

2022 ◽  
Vol 15 (715) ◽  
Author(s):  
Congci Yu ◽  
Bei Wang ◽  
Yue Zhu ◽  
Chongyang Zhang ◽  
Lili Ren ◽  
...  
Keyword(s):  
Antiviral Immunity ◽  
Innate Antiviral Immunity

Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage–induced cytokine production

2021 ◽  
Vol 14 (714) ◽  
Author(s):  
Sara H. Small ◽  
E. Jessica Tang ◽  
Ryan L. Ragland ◽  
Yaroslava Ruzankina ◽  
David W. Schoppy ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cytokine Production

Specificities of Gβγ subunits for the SNARE complex before and after stimulation of α 2a -adrenergic receptors

2021 ◽  
Vol 14 (714) ◽  
Author(s):  
Yun Young Yim ◽  
W. Hayes McDonald ◽  
Katherine M. Betke ◽  
Ali Kaya ◽  
Karren Hyde ◽  
...  
Keyword(s):  
Adrenergic Receptors ◽  
Snare Complex ◽  
Before And After ◽  
Stimulation Of

Suppression of caspase 8 activity by a coronin 1–PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling

2021 ◽  
Vol 14 (714) ◽  
Author(s):  
Mayumi Mori ◽  
Julie Ruer-Laventie ◽  
Wandrille Duchemin ◽  
Philippe Demougin ◽  
Tohnyui Ndinyanka Fabrice ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Survival ◽  
Caspase 8 ◽  
T Cell Survival

STING and arthritis

2021 ◽  
Vol 14 (714) ◽  
Author(s):  
John F. Foley
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