scholarly journals Tolerability and Plasma Drug Level Monitoring of Prolonged Subcutaneous Teicoplanin Treatment for Bone and Joint Infections

2016 ◽  
Vol 60 (10) ◽  
pp. 6365-6368 ◽  
Author(s):  
Youssef El Samad ◽  
Jean-Philippe Lanoix ◽  
Youssef Bennis ◽  
Momar Diouf ◽  
Carlo Saroufim ◽  
...  
Keyword(s):  
Injection Site Reaction ◽  
Drug Level ◽  
Parenteral Route ◽  
Joint Infections ◽  
Bone And Joint Infections ◽  
Local Adverse Event ◽  
Trough Serum ◽  
Drug Level Monitoring ◽  
Gram Positive Cocci ◽  
Level Monitoring

ABSTRACTTeicoplanin is a key drug for the treatment of multiresistant staphylococcal bone and joint infections (BJI), yet can only be administered via a parenteral route. The objective of this study was to evaluate the safety and tolerability of subcutaneous (s.c.) teicoplanin for that indication over 42 days. Thirty patients with Gram-positive cocci BJI were included. Once the target of 25 to 40 mg/liter trough serum concentration was achieved, treatment was switched from an intravenous to an s.c. route. No discontinuation of teicoplanin related to injection site reaction and no severe local adverse event were observed. On multivariate analysis, better tolerability was observed at the beginning of treatment, in patients over 70 years old, and for dosages less than 600 mg. In conclusion, we recommend s.c. administration of teicoplanin when needed.

scholarly journals Successful HCV treatment of patients on contraindicated anti-epileptic drugs: Role of drug level monitoring

2019 ◽  
Vol 70 (3) ◽  
pp. 552-554 ◽  
Author(s):  
Minou van Seyen ◽  
Elise J. Smolders ◽  
Peter van Wijngaarden ◽  
Joost P.H. Drenth ◽  
Marjan Wouthuyzen-Bakker ◽  
...  
Keyword(s):  
Drug Level ◽  
Hcv Treatment ◽  
Drug Level Monitoring ◽  
Level Monitoring

Drug level monitoring in palliative patients

2021 ◽  
pp. bmjspcare-2020-002613
Author(s):  
Joanne Bartlett ◽  
Elizabeth Freshwater
Keyword(s):  
Brain Tumour ◽  
Palliative Medicine ◽  
Drug Level ◽  
Therapeutic Drug ◽  
Primary Brain Tumour ◽  
Drug Level Monitoring ◽  
Symptoms And Signs ◽  
Level Monitoring ◽  
Palliative Patients

Palliative medicine is always patient centred and promotes the principle that no unnecessary investigations are performed. The case is reported of a patient with suspected carbamazepine toxicity presenting as progression of symptoms of primary brain tumour. A comparison is made of the symptoms and signs of toxicity versus tumour, and an aid for deciding when to perform therapeutic drug level monitoring for some common drugs.

Methotrexate Blood Level Monitoring

1985 ◽  
Vol 19 (5) ◽  
pp. 372-373 ◽  
Author(s):  
Helen St.C. Remington ◽  
Clifford C. Bailey
Keyword(s):  
Blood Level ◽  
Fluid Balance ◽  
Drug Level ◽  
Therapeutic Drug ◽  
High Dose ◽  
High Dose Therapy ◽  
Methotrexate Toxicity ◽  
Management Procedures ◽  
Drug Level Monitoring ◽  
Level Monitoring

Methotrexate toxicity can be avoided following high-dose therapy if certain management procedures are adhered to. These include careful fluid balance management and therapeutic drug level monitoring. A case is reported of an episode of methotrexate toxicity resulting from a fluid balance problem.

scholarly journals Prescribing Habits for Theophylline Preparations

1983 ◽  
Vol 76 (11) ◽  
pp. 917-919 ◽  
Author(s):  
J K Wiffen ◽  
S H D Jackson
Keyword(s):  
Slow Release ◽  
Drug Level ◽  
Prescribing Habits ◽  
Serum Drug Level ◽  
Drug Level Monitoring ◽  
Level Monitoring

Information concerning the prescriptions for theophylline preparations for a group of 80 inpatients and 55 outpatients were examined. Slow-release preparations were overwhelmingly preferred. The majority of patients were receiving low daily doses of theophylline or equivalent, and serum drug level monitoring was almost non-existent.

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