scholarly journals Determination of in vitro susceptibility of Mycobacterium avium complex isolates to antimycobacterial agents by various methods.

1987 ◽  
Vol 31 (11) ◽  
pp. 1697-1702 ◽  
Author(s):  
C B Inderlied ◽  
L S Young ◽  
J K Yamada
Keyword(s):  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
In Vitro Susceptibility ◽  
Antimycobacterial Agents

In vitro susceptibility of Mycobacterium avium complex to antibacterial agents

1987 ◽  
Vol 8 (3) ◽  
pp. 149-155 ◽  
Author(s):  
Charles E. Davis ◽  
John L. Carpenter ◽  
Sylvia Trevino ◽  
John Koch ◽  
Andre J. Ognibene
Keyword(s):  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Antibacterial Agents ◽  
In Vitro Susceptibility

scholarly journals In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex

2016 ◽  
Vol 61 (2) ◽  
Author(s):  
Barbara A. Brown-Elliott ◽  
Julie V. Philley ◽  
David E. Griffith ◽  
Foram Thakkar ◽  
Richard J. Wallace
Keyword(s):  
Cytochrome P450 ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Susceptibility Testing ◽  
Multidrug Resistant ◽  
Broth Microdilution ◽  
In Vitro Susceptibility ◽  
Content Type ◽  
In Vitro Susceptibility Testing

ABSTRACT We performed bedaquiline broth microdilution susceptibility testing using Clinical and Laboratory Standards Institute (CLSI) guidelines on 103 respiratory isolates of Mycobacterium avium complex (MAC), including multidrug-resistant isolates. Approximately 90% of isolates had bedaquiline MICs of ≤0.008 μg/ml, and 102/103 isolates had MICs of ≤0.015 μg/ml. Bedaquiline has excellent potential for use in patients with MAC infections, although for reasons of its metabolism by the cytochrome P450 system, it should not be given with rifampin.

scholarly journals Comparison of CO2 Generation (BACTEC) and Viable-Count Methods To Determine the Postantibiotic Effect of Antimycobacterial Agents against Mycobacterium avium Complex

1998 ◽  
Vol 42 (1) ◽  
pp. 184-187 ◽  
Author(s):  
George G. Zhanel ◽  
Marilyn H. Saunders ◽  
Joyce N. Wolfe ◽  
Daryl J. Hoban ◽  
James A. Karlowsky ◽  
...  
Keyword(s):  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Viable Count ◽  
Postantibiotic Effect ◽  
Count Method ◽  
Antimycobacterial Agents

ABSTRACT The postantibiotic effects (PAEs) of antimycobacterial agents determined with a BACTEC TB-460 instrument (CO2 production) and by a traditional viable-count method against Mycobacterium avium complex (MAC) were not significantly different (P > 0.05). The longest PAEs following a 2-h exposure to 2× the MIC were induced by amikacin (10.3 h), rifampin (9.7 h), and rifabutin (9.5 h), while the shortest PAEs resulted from clofazimine (1.7 h) and ethambutol (1.1 h) exposure. CO2 generation is a valid and efficient means of determining in vitro PAEs against MAC.

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