scholarly journals In Vitro Susceptibilities of 400 Spanish Isolates ofNeisseria gonorrhoeae to Gemifloxacin and 11 Other Antimicrobial Agents

2000 ◽  
Vol 44 (9) ◽  
pp. 2543-2544 ◽  
Author(s):  
S. Berrón ◽  
J. A. Vázquez ◽  
M. J. Giménez ◽  
L. de la Fuente ◽  
L. Aguilar
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Antimicrobial Agents ◽  
Vitro Activity ◽  
Penicillin Resistance ◽  
In Vitro Activity ◽  
Ofneisseria Gonorrhoeae ◽  
High Level

ABSTRACT The in vitro activity of gemifloxacin versus those of 11 other antimicrobial agents against 400 strains of Neisseria gonorrhoeae was determined by microdilution with supplemented GC agar. A total of 37.5% of the strains were β-lactamase positive. A total of 70 and 6.4% of the β-lactamase-negative strains exhibited intermediate and high-level penicillin resistance, respectively. Ceftriaxone and gemifloxacin were the most active drugs (MICs at which 90% of isolates are inhibited, 0.01 versus 0.007 μg/ml, respectively), with 100% of strains inhibited by 0.12 μg/ml.

scholarly journals In vitro activity of 14 antimicrobial agents against Neisseria gonorrhoeae from Spain.

1987 ◽  
Vol 63 (3) ◽  
pp. 215-216
Author(s):  
M C Lozano ◽  
J C Palomares ◽  
R Prados ◽  
E J Perea
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Antimicrobial Agents ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals In-vitro activity of antimicrobial agents against Neisseria gonorrhoeae in Brussels.

1978 ◽  
Vol 54 (5) ◽  
pp. 309-315
Author(s):  
R Vanhoof ◽  
M P Vanderlinden ◽  
J M Hubrechts ◽  
J P Butzler ◽  
E Yourassowsky
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Antimicrobial Agents ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals High in vitro activity of DIS-73285, a novel antimicrobial with a new mechanism of action, against MDR and XDR Neisseria gonorrhoeae

2020 ◽  
Vol 75 (11) ◽  
pp. 3244-3247
Author(s):  
Susanne Jacobsson ◽  
Clive Mason ◽  
Nawaz Khan ◽  
Paul Meo ◽  
Magnus Unemo
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Small Molecule ◽  
Mechanism Of Action ◽  
Vitro Activity ◽  
In Vivo Studies ◽  
In Vitro Activity ◽  
Agar Dilution ◽  
High Level

Abstract Background The rising incidence of antimicrobial resistance in Neisseria gonorrhoeae may result in untreatable gonorrhoea in certain circumstances and development of novel antimicrobials is urgently needed. Objectives To evaluate the in vitro activity of a novel small-molecule antimicrobial with a new mechanism of action, DIS-73285, against a large geographically, temporally and genetically diverse collection of clinical N. gonorrhoeae isolates and reference strains, including various types of high-level resistant, MDR and XDR gonococcal isolates (n = 262). Methods MICs (mg/L) of DIS-73285 were determined by agar dilution and by Etest for ceftriaxone, cefixime, azithromycin, ciprofloxacin, ampicillin, spectinomycin and tetracycline. Results DIS-73285 was substantially more potent than any of the currently or previously used therapeutic antimicrobials, with MICs ranging from ≤0.001 to 0.004 mg/L, and the MIC50, MIC90 and modal MIC all ≤0.001 mg/L (lowest MIC tested). No correlation with the MICs of DIS-73285 and the MICs of any of the currently or previously used antimicrobials was observed. Conclusions The novel chemotype, small-molecule antimicrobial DIS-73285, demonstrated high in vitro potency against all tested N. gonorrhoeae isolates. Further in vitro and in vivo studies, evaluating efficacy, resistance emergence, pharmacokinetic/pharmacodynamic parameters, toxicity and safety, should be conducted to evaluate DIS-73285 as a therapy specifically for urogenital and extra-genital gonorrhoea.

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