scholarly journals Antimicrobial Activity and Spectrum of PPI-0903M (T-91825), a Novel Cephalosporin, Tested against a Worldwide Collection of Clinical Strains

2005 ◽  
Vol 49 (8) ◽  
pp. 3501-3512 ◽  
Author(s):  
Helio S. Sader ◽  
Thomas R. Fritsche ◽  
Koné Kaniga ◽  
Yigong Ge ◽  
Ronald N. Jones
Keyword(s):  
Antimicrobial Activity ◽  
Multidrug Resistant ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Gram Negative ◽  
Similar Activity ◽  
Gram Positive Bacteria ◽  
Medical Centers

ABSTRACT PPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrated broader in vitro activity against gram-positive bacteria, particularly against multidrug-resistant staphylococci and streptococci of current clinical concern, than currently available extended-spectrum cephalosporins while maintaining similar activity against gram-negative pathogens.

scholarly journals Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates

2010 ◽  
Vol 54 (9) ◽  
pp. 3974-3977 ◽  
Author(s):  
Michelle M. Butler ◽  
John D. Williams ◽  
Norton P. Peet ◽  
Donald T. Moir ◽  
Rekha G. Panchal ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Indole Compounds ◽  
Clinical Pathogens ◽  
High Level

ABSTRACT Antimicrobial susceptibilities of 233 Gram-positive and 180 Gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of Gram-positive bacteria, with MIC90 values of 0.004 to 0.5 μg/ml. One bis-indole, MBX 1162, exhibited potent activity against all Gram-negative strains, with MIC90 values of 0.12 to 4 μg/ml, even against high-level-resistant pathogens, and compared favorably to all comparator antibiotics. The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens.

scholarly journals In Vitro and In Vivo Antibacterial Activities of DW-224a, a New Fluoronaphthyridone

2006 ◽  
Vol 50 (6) ◽  
pp. 2261-2264 ◽  
Author(s):  
Hee-Soo Park ◽  
Hyun-Joo Kim ◽  
Min-Jung Seol ◽  
Dong-Rack Choi ◽  
Eung-Chil Choi ◽  
...  
Keyword(s):  
Antibacterial Activities ◽  
The Other ◽  
Vitro Activity ◽  
Gram Negative Bacteria ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria

ABSTRACT DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.

scholarly journals In vitro activity of para-guanidinoethylcalix[4]arene against susceptible and antibiotic-resistant Gram-negative and Gram-positive bacteria

2007 ◽  
Vol 60 (3) ◽  
pp. 575-581 ◽  
Author(s):  
Marion Grare ◽  
Maxime Mourer ◽  
Stéphane Fontanay ◽  
Jean-Bernard Regnouf-de-Vains ◽  
Chantal Finance ◽  
...  
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
Gram Positive Bacteria

scholarly journals In Vitro Antimicrobial Activity of Doripenem, a New Carbapenem

2004 ◽  
Vol 48 (4) ◽  
pp. 1384-1396 ◽  
Author(s):  
Yigong Ge ◽  
Matthew A. Wikler ◽  
Daniel F. Sahm ◽  
Renée S. Blosser-Middleton ◽  
James A. Karlowsky
Keyword(s):  
Antimicrobial Activity ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Gram Negative ◽  
In Vitro Antimicrobial Activity

ABSTRACT The doripenem MICs at which 90% of the tested strains were inhibited ranged from 0.03 to 1 μg/ml for 10 species of Enterobacteriaceae (n = 351), from 0.03 to 0.12 μg/ml for oxacillin-susceptible staphylococci (n = 119), from 4 to 32 μg/ml for oxacillin-resistant staphylococci (n = 64), from ≤0.008 to 0.06 μg/ml for penicillin-susceptible streptococci (n = 132), and from 1 to 4 μg/ml for penicillin-resistant streptococci (n = 51). Overall, doripenem demonstrated in vitro activity similar to that of meropenem against gram-negative pathogens and to that of imipenem against gram-positive pathogens.

scholarly journals In Vitro Antibacterial Activity of CE-156811, a Novel Analog Derived from Hygromycin A

2008 ◽  
Vol 52 (7) ◽  
pp. 2663-2666 ◽  
Author(s):  
Gregory G. Stone ◽  
Dennis Girard ◽  
Steve Finegan ◽  
Joan Duignan ◽  
John Schafer ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Multidrug Resistant ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
In Vitro Antibacterial Activity

ABSTRACT We evaluated a novel truncated hygromycin A analog in which the furanose ring was replaced with a 2-fluoro-2-cyclopropylethyl substituent for its activity against multidrug resistant gram-positive bacteria and compared its activity to the activities of linezolid, quinupristin-dalfopristin, and vancomycin. CE-156811 demonstrated robust in vitro activity against gram-positive bacteria that was comparable to that of linezolid.

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