scholarly journals Deoxyribonucleic Acid-Directed In Vitro Synthesis of ilv-Specific Messenger Ribonucleic Acid by Extracts of Escherichia coli K-12

1974 ◽  
Vol 120 (3) ◽  
pp. 1238-1248 ◽  
Author(s):  
David E. Smolin ◽  
H. E. Umbarger
Keyword(s):  
Escherichia Coli ◽  
Ribonucleic Acid ◽  
Deoxyribonucleic Acid ◽  
In Vitro Synthesis ◽  
Messenger Ribonucleic Acid ◽  
K 12

scholarly journals Accumulation of untranslated lactose-specific messenger ribonucleic acid during catabolite repression in Escherichia coli

1971 ◽  
Vol 122 (2) ◽  
pp. 219-224 ◽  
Author(s):  
M. Aboud ◽  
M. Burger
Keyword(s):  
Escherichia Coli ◽  
Carbon Source ◽  
Cyclic Amp ◽  
Direct Effect ◽  
Ribonucleic Acid ◽  
Catabolite Repression ◽  
Mrna Accumulation ◽  
Messenger Ribonucleic Acid ◽  
K 12 ◽  
Specific Mrna

When Escherichia coli K-12 Hfr.H was induced to synthesize β-galactosidase in the presence of glucose, an untranslated lactose-specific mRNA (lac-mRNA), protected from decay, was found to accumulate progressively within the cells. The lac-mRNA accumulation was unaffected by the carbon source on which the cells had been grown before the induction. The amount of the lac-mRNA available for translation was affected by catabolite repression and 3′:5′-cyclic AMP, but it remained unclear whether this was a direct effect on the formation of the lac-mRNA or a consequence of the effect on its translation.

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