Investigation by syringe method of effect of tampons on production in vitro of toxic shock syndrome toxin 1 by Staphylococcus aureus.

1987 ◽  
Vol 25 (1) ◽  
pp. 87-90 ◽  
Author(s):  
A C Lee ◽  
B A Crass ◽  
M S Bergdoll
Keyword(s):  
Staphylococcus Aureus ◽  
Toxic Shock Syndrome ◽  
Toxic Shock ◽  
Toxic Shock Syndrome Toxin

Growth of Staphylococcus aureus and Synthesis of Toxic Shock Syndrome Toxin 1 in Different in Vitro Systems

1989 ◽  
Vol 11 (Supplement_1) ◽  
pp. S188-S196 ◽  
Author(s):  
Jerry J. Kirkland ◽  
Cynthia A. Ryan ◽  
Karen A. Kohrman ◽  
Pamela J. Danneman
Keyword(s):  
Staphylococcus Aureus ◽  
Toxic Shock Syndrome ◽  
Toxic Shock ◽  
In Vitro Systems ◽  
Toxic Shock Syndrome Toxin

scholarly journals Glycerol Monolaurate and Dodecylglycerol Effects on Staphylococcus aureus and Toxic Shock Syndrome Toxin-1 In Vitro and In Vivo

PLoS ONE ◽  
2009 ◽  
Vol 4 (10) ◽  
pp. e7499 ◽  
Author(s):  
Ying-Chi Lin ◽  
Patrick M. Schlievert ◽  
Michele J. Anderson ◽  
Christina L. Fair ◽  
Matthew M. Schaefers ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Toxic Shock Syndrome ◽  
Toxic Shock ◽  
Glycerol Monolaurate ◽  
Toxic Shock Syndrome Toxin

scholarly journals Influence of the Vaginal Microbiota on Toxic Shock Syndrome Toxin 1 Production by Staphylococcus aureus

2013 ◽  
Vol 79 (6) ◽  
pp. 1835-1842 ◽  
Author(s):  
Roderick A. MacPhee ◽  
Wayne L. Miller ◽  
Gregory B. Gloor ◽  
John K. McCormick ◽  
Jo-Anne Hammond ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Toxic Shock Syndrome ◽  
Pathogenic Bacteria ◽  
Toxin Production ◽  
Clinical Samples ◽  
Toxic Shock ◽  
Aerobic Vaginitis ◽  
Content Type ◽  
Toxic Shock Syndrome Toxin

ABSTRACTMenstrual toxic shock syndrome (TSS) is a serious illness that afflicts women of premenopausal age worldwide and arises from vaginal infection byStaphylococcus aureusand concurrent production of toxic shock syndrome toxin-1 (TSST-1). Studies have illustrated the capacity of lactobacilli to reduceS. aureusvirulence, including the capacity to suppress TSST-1. We hypothesized that an aberrant microbiota characteristic of pathogenic bacteria would induce the increased production of TSST-1 and that this might represent a risk factor for the development of TSS. AS. aureusTSST-1 reporter strain was grown in the presence of vaginal swab contents collected from women with a clinically healthy vaginal status, women with an intermediate status, and those diagnosed with bacterial vaginosis (BV). Bacterial supernatant challenge assays were also performed to test the effects of aerobic vaginitis (AV)-associated pathogens toward TSST-1 production. While clinical samples from healthy and BV women suppressed toxin production,in vitrostudies demonstrated thatStreptococcus agalactiaeandEnterococcusspp. significantly induced TSST-1 production, while someLactobacillusspp. suppressed it. The findings suggest that women colonized byS. aureusand with AV, but not BV, may be more susceptible to menstrual TSS and would most benefit from prophylactic treatment.

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