scholarly journals Quantification of Proviral Load of Human Immunodeficiency Virus Type 2 Subtypes A and B Using Real-Time PCR

2001 ◽  
Vol 39 (12) ◽  
pp. 4264-4268 ◽  
Author(s):  
F. Damond ◽  
D. Descamps ◽  
I. Farfara ◽  
J. N. Telles ◽  
S. Puyeo ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Real Time ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Real Time Pcr ◽  
Proviral Load ◽  
Immunodeficiency Virus

scholarly journals Rapid Discrimination between Human Immunodeficiency Virus Type 2 Groups A and B by Real-Time PCR

2004 ◽  
Vol 42 (12) ◽  
pp. 5866-5870 ◽  
Author(s):  
J.-C. Plantier ◽  
M. Gueudin ◽  
F. de Oliveira ◽  
F. Damond ◽  
V. Lemee ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Real Time ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Real Time Pcr ◽  
Immunodeficiency Virus ◽  
Rapid Discrimination

scholarly journals Gag-Specific CD4+ T-Cell Frequency Is Inversely Correlated with Proviral Load and Directly Correlated with Immune Activation in Infection with Human Immunodeficiency Virus Type 2 (HIV-2) but Not HIV-1

2008 ◽  
Vol 82 (19) ◽  
pp. 9795-9799 ◽  
Author(s):  
Russell B. Foxall ◽  
Catarina S. Cortesão ◽  
Adriana S. Albuquerque ◽  
Rui S. Soares ◽  
Rui M. M. Victorino ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immune Activation ◽  
Proviral Load ◽  
Viral Control ◽  
Peripheral Blood Mononuclear ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Human immunodeficiency virus type 2 (HIV-2) infection, unlike HIV-1 infection, is normally characterized by low rates of CD4 depletion and low-to-undetectable viremia. We found that the frequency of Gag-specific CD4+ T cells featured positive correlations with the expression of markers of CD4 activation and a negative correlation with peripheral blood mononuclear cell-associated proviral load in infection with HIV-2, in contrast with HIV-1. Moreover, HIV-2-infected individuals exhibited a greater ability to respond to HIV-1 Gag peptides (heterologous responses). Our data suggest a potential link between HIV-2-specific CD4 responses, immune activation, and viral control, which may in turn relate to the better prognosis associated with HIV-2 infection.

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