scholarly journals Pulsed-Field Gel Electrophoresis Can Yield DNA Fingerprints of Degradation-Susceptible Clostridium difficile Strains

2002 ◽  
Vol 40 (9) ◽  
pp. 3546-3547 ◽  
Author(s):  
W. N. Fawley ◽  
M. H. Wilcox ◽  
C. H. W. Klaassen ◽  
H. A. de Valk-Van Haren ◽  
A. M. Horrevorts
Keyword(s):  
Clostridium Difficile ◽  
Gel Electrophoresis ◽  
Pulsed Field Gel Electrophoresis ◽  
Dna Fingerprints ◽  
Pulsed Field

scholarly journals First isolation of Clostridium difficile 027 in Japan

2007 ◽  
Vol 12 (2) ◽  
Author(s):  
H Kato ◽  
Y Ito ◽  
R van den Berg ◽  
E J Kuijper ◽  
Y Arakawa
Keyword(s):  
Clostridium Difficile ◽  
North American ◽  
Gel Electrophoresis ◽  
Pseudomembranous Colitis ◽  
Pulsed Field Gel Electrophoresis ◽  
Pulsed Field ◽  
Variant Strain ◽  
Ribotype 027 ◽  
Pcr Ribotype 027

We report the first isolation of a variant strain of Clostridium difficile from a patient with pseudomembranous colitis in Japan. The strain was chararacterised as North American pulsed field gel electrophoresis type 1 (NAP1), PCR ribotype 027, toxinotype III.

Moxifloxacin Therapy as a Risk Factor forClostridium difficile–Associated Disease During an Outbreak: Attempts to Control a New Epidemic Strain

2007 ◽  
Vol 28 (2) ◽  
pp. 198-201 ◽  
Author(s):  
Priscilla Biller ◽  
Beth Shank ◽  
Leah Lind ◽  
Meghan Brennan ◽  
Lisa Tkatch ◽  
...  
Keyword(s):  
Risk Factor ◽  
Clostridium Difficile ◽  
North American ◽  
Gel Electrophoresis ◽  
Pulsed Field Gel Electrophoresis ◽  
Epidemic Strain ◽  
Pulsed Field

An outbreak ofClostridium difficile-associated disease (CDAD) caused by the epidemic North American pulsed-field gel electrophoresis type 1 (NAP1) strain began after a formulary change from levofloxacin to moxifloxacin. Cases of CDAD were associated with moxifloxacin use, but a formulary change back to levofloxacin failed to reduce rates of disease. Substituting use of one fluoroquinolone with use of another without also controlling the overall use of drugs from this class is unlikely to control outbreaks caused by the NAP1 strain ofC. difficile.

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