Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus.

1986 ◽  
Vol 60 (2) ◽  
pp. 771-775 ◽  
Author(s):  
M M Lightfoote ◽  
J E Coligan ◽  
T M Folks ◽  
A S Fauci ◽  
M A Martin ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Structural Characterization ◽  
Acquired Immunodeficiency Syndrome ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

scholarly journals Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide

2002 ◽  
Vol 283 (6) ◽  
pp. H2363-H2370 ◽  
Author(s):  
Roy L. Sutliff ◽  
Sergey Dikalov ◽  
Daiana Weiss ◽  
Jeremy Parker ◽  
Scott Raidel ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Acquired Immunodeficiency Syndrome ◽  
Vascular Function ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Reverse Transcriptase Inhibitors ◽  
Nucleoside Reverse Transcriptase Inhibitors ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Endothelium Dependent Relaxation

Nucleoside reverse transcriptase inhibitors (NRTIs) have been used successfully to reduce acquired immunodeficiency syndrome mortality. However, the use of these compounds is associated with numerous tissue toxicities, including cardiomyopathy. These studies address the effects of NRTIs on vascular function. Functional assays of contraction and relaxation were performed on isolated mouse aorta segments obtained from FVB/n mice exposed to zidovudine (AZT), stavudine, or water for 35 days. AZT and stavudine treatment impaired sensitivity to endothelium-dependent relaxation by acetylcholine. Dihydroethidium staining revealed that AZT treatment was associated with an increase in superoxide levels. Pretreatment of AZT-treated vessels with tiron (1 mM), a free radical scavenger, restored endothelium-dependent relaxation in mice. In cellular preparations, electron spin resonance measurements revealed elevated superoxide in cultured endothelial cells exposed to AZT; elevation was dependent on the length of exposure. These results indicate that NRTIs impair endothelium-dependent relaxation by increasing superoxide levels and suggest that NRTI therapy contributes to cardiovascular complications in acquired immunodeficiency syndrome.

scholarly journals Clinical and Virologic Characterization of Acyclovir‐Resistant Varicella‐Zoster Viruses Isolated from 11 Patients with Acquired Immunodeficiency Syndrome

2001 ◽  
Vol 33 (12) ◽  
pp. 2061-2067 ◽  
Author(s):  
Estelle Saint‐Léger ◽  
Eric Caumes ◽  
Guillaume Breton ◽  
Danielle Douard ◽  
Philippe Saiag ◽  
...  
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Varicella Zoster ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome
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