scholarly journals Mouse mammary tumor virus with rearranged long terminal repeats causes murine lymphomas.

1993 ◽  
Vol 67 (1) ◽  
pp. 112-118 ◽  
Author(s):  
S Yanagawa ◽  
K Kakimi ◽  
H Tanaka ◽  
A Murakami ◽  
Y Nakagawa ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Long Terminal Repeats ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Terminal Repeats

scholarly journals Identification of Notch1 as a Frequent Target for Provirus Insertional Mutagenesis in T-Cell Lymphomas Induced by Leukemogenic Mutants of Mouse Mammary Tumor Virus

2000 ◽  
Vol 74 (20) ◽  
pp. 9786-9791 ◽  
Author(s):  
Shin-ichi Yanagawa ◽  
Jong-Seo Lee ◽  
Kazuhiro Kakimi ◽  
Yukihiro Matsuda ◽  
Tasuku Honjo ◽  
...  
Keyword(s):  
T Cell ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Insertional Mutagenesis ◽  
Wild Type Mouse ◽  
Long Terminal Repeats ◽  
Mammary Tumor Virus ◽  
T Cell Lymphomas ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

ABSTRACT In contrast to wild-type mouse mammary tumor virus (MMTV), the MMTV mutants with specific deletions in the U3 region of their long terminal repeats cause T-cell lymphomas. In 30% of T-cell lymphomas arising in BALB/c mice infected with MLA-MMTV, a leukemogenic MMTV mutant, we have found that MMTV proviruses were integrated into a short region of theNotch1 genome, so that truncated Notch1transcripts encoding the transmembrane and the cytoplasmic domains of Notch1 protein could be expressed. Thus, Notch1 is a major target of provirus insertional mutagenesis in these T-cell lymphomas.

Electron Microscopy of the Nucleic Acid of Mouse Mammary Tumor Virus

1968 ◽  
Vol 26 ◽  
pp. 22-23
Author(s):  
N. H. Sarkar ◽  
Dan H. Moore
Keyword(s):  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Ammonium Acetate ◽  
Dry Weight ◽  
Mouse Tumor ◽  
Mammary Tumor Virus ◽  
Rna Molecules ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
The Subject

Mouse mammary tumor virus (MTV) is believed to contain about 0.8% single stranded ribonucleic acid (RNA). This value of RNA content was estimated on a dry weight basis. The subject of this report is an attempt to visualize the RNA molecules of MTV particles.MTV particles were isolated from RIII mouse (tumor incidence approximately 80%) milk according to the method described by Lyons and Moore. Purified virions from 5 ml of milk were finally suspended in 0.2 ml of PBS, pH 7.4 and was mixed with an equal volume of pronase (5 mg/ml). This mixture was incubated at 37°C for an hour. RNA was extracted three times using freshly prepared cold phenol. It was then treated three times with cold ethyl ether to remove any trace of phenol. The RNA thus extracted was divided into two parts. One part was diluted four fold with 8M urea to avoid aggregation of the molecules. The other part was left untreated. Both samples were then mixed with an equal volume of 1M ammonium acetate, adjusted to pH 8.0 with NH3 containing chymotrypsin at a concentration of 0.01%.

A novel V beta 2-specific endogenous mouse mammary tumor virus which is capable of producing a milk-borne exogenous virus.

1995 ◽  
Vol 69 (11) ◽  
pp. 7269-7273 ◽  
Author(s):  
N Niimi ◽  
W Wajjwalku ◽  
Y Ando ◽  
N Nakamura ◽  
M Ueda ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Mammary Tumor Virus ◽  
Exogenous Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Beta 2
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