scholarly journals Identification of factor-binding sites in the duck hepatitis B virus enhancer and in vivo effects of enhancer mutations.

1994 ◽  
Vol 68 (4) ◽  
pp. 2286-2296 ◽  
Author(s):  
C Liu ◽  
W S Mason ◽  
J B Burch
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Binding Sites ◽  
Duck Hepatitis B Virus ◽  
Factor Binding ◽  
Duck Hepatitis ◽  
B Virus ◽  
In Vivo Effects

Effect of 3′-azido-3′-deoxythymidine on replication of duck hepatitis B virus in vivo and in vitro

1989 ◽  
Vol 29 (4) ◽  
pp. 244-248 ◽  
Author(s):  
Hideaki Haritani ◽  
Toshikazu Uchida ◽  
Yasunori Okuda ◽  
Toshio Shikata
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Duck Hepatitis B Virus ◽  
Duck Hepatitis ◽  
B Virus

Duck hepatitis B virus polymerase gene mutants associated with resistance to lamivudine have a decreased replication capacity in vitro and in vivo

2001 ◽  
Vol 34 (1) ◽  
pp. 114-122 ◽  
Author(s):  
Béatrice Seignères ◽  
Stéphanie Aguesse-Germon ◽  
Christian Pichoud ◽  
Isabelle Vuillermoz ◽  
Catherine Jamard ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Replication Capacity ◽  
Polymerase Gene ◽  
Duck Hepatitis B Virus ◽  
Duck Hepatitis ◽  
B Virus

Effect ofPhyllanthus amarus on duck hepatitis B virus replication in vivo

1990 ◽  
Vol 32 (4) ◽  
pp. 212-218 ◽  
Author(s):  
Jianzhang Niu ◽  
Yanyan Wang ◽  
Ming Qiao ◽  
Eric Gowans ◽  
Patrick Edwards ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Duck Hepatitis B Virus ◽  
Duck Hepatitis ◽  
B Virus

scholarly journals Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo.

1996 ◽  
Vol 40 (3) ◽  
pp. 792-794 ◽  
Author(s):  
P Hafkemeyer ◽  
A Keppler-Hafkemeyer ◽  
M A al Haya ◽  
M von Janta-Lipinski ◽  
E Matthes ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Strong Inhibitor ◽  
Duck Hepatitis B Virus ◽  
Duck Hepatitis ◽  
B Virus ◽  
Dependent Inhibition ◽  
Dose Dependent Inhibition

The antiviral activity of 2',3'-dideoxy-3'-fluoroguanosine (FdG) or its triphosphate was evaluated in the duck hepatitis B virus (DHBV) system in vitro and in vivo. In primary DHBV-infected hepatocytes FdG results in a dose-dependent inhibition of viral replication with a nearly complete inhibition at a concentration of 1 microM. Also in vivo, FdG treatment of DHBV-infected ducklings reduces DHBV DNA replication by more than 90%. These data demonstrate that FdG is a strong inhibitor of DHBV replication in vitro and in vivo.

Ganciclovir is a potent inhibitor of duck hepatitis B virus replication in vivo

1991 ◽  
Vol 15 ◽  
pp. 131
Author(s):  
Tim Shaw ◽  
Scott Bowden ◽  
Yanyan Wang ◽  
Gilda Civitico ◽  
Stephen Locarnini
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Potent Inhibitor ◽  
Duck Hepatitis B Virus ◽  
Duck Hepatitis ◽  
B Virus

scholarly journals The guanine nucleoside analog penciclovir is active against chronic duck hepatitis B virus infection in vivo.

1996 ◽  
Vol 40 (2) ◽  
pp. 413-418 ◽  
Author(s):  
E Lin ◽  
C Luscombe ◽  
Y Y Wang ◽  
T Shaw ◽  
S Locarnini
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nucleoside Analog ◽  
Genome Replication ◽  
Viral Dna ◽  
Duck Hepatitis B Virus ◽  
Protein Levels ◽  
Duck Hepatitis ◽  
B Virus

Ducks congenitally infected with duck hepatitis B virus (HBV) were treated with the antiviral guanine nucleoside analog penciclovir for 4 weeks at a dose of 10 mg/kg of body weight per day. The effects of treatment on viremia and intrahepatic viral genome replication, transcription, and translation were examined. In seven of eight penciclovir-treated ducks, viremia was barely detectable after a week of treatment. After 4 weeks of treatment, molecular hybridization studies showed that intrahepatic viral DNA, RNA, and protein levels were significantly reduced compared with those in placebo-treated controls. Synthesis of all viral replicative intermediates, including the normally persistent viral supercoiled DNA species, was inhibited by penciclovir treatment. Examination of liver tissue sections after in situ DNA hybridization or immunohistochemical staining confirmed that viral DNA and protein synthesis had been profoundly inhibited in most hepatic parenchymal cells. However, small subpopulations of cells, in particular the small bile duct epithelial cells, remained strongly positive for duck HBV antigens and DNA despite treatment. There was no evidence of toxicity associated with penciclovir therapy. This study confirms the safety and potent antihepadnaviral activity of penciclovir in vivo but indicates that further improvements in antiviral therapy will be required to completely eliminate HBV infection.

2‘,3’-dideoxy-3‘-fluoroguanosine inhibits duck hepatitis B virus in vivo

1996 ◽  
Vol 3 (2) ◽  
pp. 61-65 ◽  
Author(s):  
B. Lofgren ◽  
K. Vickery ◽  
Y. Y. Zhang ◽  
E. Nordenfelt
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Duck Hepatitis B Virus ◽  
Duck Hepatitis ◽  
B Virus

Effects of Phyllanthus plant extracts on duck hepatitis B virus in vitro and in vivo

1992 ◽  
Vol 18 (2) ◽  
pp. 127-138 ◽  
Author(s):  
Andrew Shead ◽  
Karen Vickery ◽  
Aniko Pajkos ◽  
Robert Medhurst ◽  
John Freiman ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Plant Extracts ◽  
Duck Hepatitis B Virus ◽  
Duck Hepatitis ◽  
B Virus

In vivo neutralization of duck hepatitis B virus by antibodies specific to the N-terminal portion of pre-S protein

Virology ◽  
1991 ◽  
Vol 185 (1) ◽  
pp. 446-450 ◽  
Author(s):  
Véronique Lambert ◽  
Sylvie Chassot ◽  
Alan Kay ◽  
Christian Trepo ◽  
Lucyna Cova
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Terminal Portion ◽  
Duck Hepatitis B Virus ◽  
S Protein ◽  
Duck Hepatitis ◽  
B Virus
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