scholarly journals Lentiviral Transduction of Dendritic Cells Confers Protective Antiviral Immunity In Vivo

2004 ◽  
Vol 78 (14) ◽  
pp. 7843-7845 ◽  
Author(s):  
Shohreh Zarei ◽  
Shahnaz Abraham ◽  
Jean-Francois Arrighi ◽  
Olivier Haller ◽  
Thomas Calzascia ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Viral Infections ◽  
Cytotoxic T Lymphocyte ◽  
Antiviral Immunity ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocyte Response ◽  
Vaccine Candidates ◽  
Virus Model ◽  
Cytotoxic T Lymphocyte Response

ABSTRACT Control of a viral infection in vivo requires a rapid and efficient cytotoxic-T-lymphocyte response. We demonstrate that lentivirus-mediated introduction of antigen in dendritic cells confers a protective antiviral immunity in vivo in a lymphocytic choriomeningitis virus model. Therefore, lentiviral vectors may be excellent vaccine candidates for viral infections.

In Vivo Analysis of Adenovirus-Specific Cytotoxic T Lymphocyte Response in Mice Deficient in CD28, Fas Ligand, and Perforin

2006 ◽  
Vol 0 (0) ◽  
pp. 060801084750020
Author(s):  
Jian Chen ◽  
Hui-Chen Hsu ◽  
Allan J. Zajac ◽  
Qi Wu ◽  
Pingar Yang ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Fas Ligand ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Response ◽  
In Vivo Analysis ◽  
Cytotoxic T Lymphocyte Response
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