scholarly journals Epstein-Barr Virus Latent Membrane Protein LMP-2A Is Sufficient for Transactivation of the Human Endogenous Retrovirus HERV-K18 Superantigen

2004 ◽  
Vol 78 (14) ◽  
pp. 7852-7860 ◽  
Author(s):  
Natalie Sutkowski ◽  
Gang Chen ◽  
German Calderon ◽  
Brigitte T. Huber
Keyword(s):  
T Cells ◽  
Membrane Protein ◽  
Epstein Barr Virus ◽  
Endogenous Retrovirus ◽  
Latent Membrane Protein ◽  
Human Endogenous Retrovirus ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Latent Membrane Protein

ABSTRACT Superantigens are microbial proteins that strongly stimulate T cells. We described previously that the Epstein-Barr virus (EBV) transactivates a superantigen encoded by the human endogenous retrovirus, HERV-K18. We now report that the transactivation is dependent upon the EBV latent cycle proteins. Moreover, LMP-2A is sufficient for induction of HERV-K18 superantigen activity.

The relationships between Epstein-Barr virus latent membrane protein 1 and regulatory T cells in Hodgkin's lymphoma

2007 ◽  
Vol 35 (4) ◽  
pp. 596-604 ◽  
Author(s):  
Neil A. Marshall ◽  
Dominic J. Culligan ◽  
Jane Tighe ◽  
Peter W. Johnston ◽  
Robert N. Barker ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Membrane Protein ◽  
Epstein Barr Virus ◽  
Latent Membrane Protein ◽  
Hodgkin's Lymphoma ◽  
Latent Membrane Protein 1 ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Latent Membrane Protein

Epstein-Barr virus latent membrane protein 1 mRNA is expressed in a significant proportion of patients with chronic lymphocytic leukemia

Cancer ◽  
2010 ◽  
Vol 116 (4) ◽  
pp. 880-887 ◽  
Author(s):  
Jeffrey J. Tarrand ◽  
Michael J. Keating ◽  
Apostolia M. Tsimberidou ◽  
Susan O'Brien ◽  
Rocco P. LaSala ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Membrane Protein ◽  
Epstein Barr Virus ◽  
Significant Proportion ◽  
Latent Membrane Protein ◽  
Lymphocytic Leukemia ◽  
Latent Membrane Protein 1 ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Latent Membrane Protein
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