Long-Term Presence of Virus-Specific Plasma Cells in Sensory Ganglia and Spinal Cord following Intravaginal Inoculation of Herpes Simplex Virus Type 2
2005 ◽
Vol 79
(17)
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pp. 11537-11540
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ABSTRACT The tissue sites of long-term herpes simplex virus type 2 (HSV-2)-specific antibody production in mice and guinea pigs were identified. In addition to secondary lymphoid tissue and bone marrow, HSV-specific plasma cells were detected in spinal cords of mice up to 10 months after intravaginal inoculation with a thymidine kinase-deficient HSV-2 strain and in lumbosacral ganglia and spinal cords of guinea pigs inoculated with HSV-2 strain MS. The long-term retention of virus-specific plasma cells in the peripheral and central nervous systems following HSV infection may be important for resistance to reinfection of neuronal tissues or may play a role in modulation of reactivation from latency.
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1986 ◽
Vol 154
(1)
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pp. 134-140
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1986 ◽
Vol 153
(6)
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pp. 1055-1061
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1992 ◽
Vol 36
(4)
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pp. 303-308
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2015 ◽
Vol 24
(1)
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pp. 19-27
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2016 ◽
Vol 439
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pp. 1-7
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