scholarly journals An N-Linked Glycoprotein with α(2,3)-Linked Sialic Acid Is a Receptor for BK Virus

2005 ◽  
Vol 79 (22) ◽  
pp. 14442-14445 ◽  
Author(s):  
Aisling S. Dugan ◽  
Sylvia Eash ◽  
Walter J. Atwood
Keyword(s):  
Sialic Acid ◽  
Renal Transplant ◽  
Bk Virus ◽  
Human Polyomavirus ◽  
Cellular Receptor ◽  
Renal Transplant Recipients ◽  
Critical Component ◽  
Transplant Recipients ◽  
Susceptibility To Infection ◽  
Infection Inhibition

ABSTRACT BK virus (BKV) is a common human polyomavirus infecting >80% of the population worldwide. Infection with BKV is asymptomatic, but reactivation in renal transplant recipients can lead to polyomavirus-associated nephropathy. In this report, we show that enzymatic removal of α(2,3)-linked sialic acid from cells inhibited BKV infection. Reconstitution of asialo cells with α(2,3)-specific sialyltransferase restored susceptibility to infection. Inhibition of N-linked glycosylation with tunicamycin reduced infection, but inhibition of O-linked glycosylation did not. An O-linked-specific α(2,3)-sialyltransferase was unable to restore infection in asialo cells. Taken together, these data indicate that an N-linked glycoprotein containing α(2,3)-linked sialic acid is a critical component of the cellular receptor for BKV.

scholarly journals BK Virus-Specific Antibodies and BKV DNA in Renal Transplant Recipients with BKV Nephritis

2005 ◽  
Vol 5 (11) ◽  
pp. 2719-2724 ◽  
Author(s):  
Sundaram Hariharan ◽  
Eric P. Cohen ◽  
Brahm Vasudev ◽  
Rimas Orentas ◽  
Raphael P. Viscidi ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Specific Antibodies

BK virus replication in renal transplant recipients: Analysis of potential risk factors may contribute in reactivation

2017 ◽  
Vol 96 ◽  
pp. 7-11 ◽  
Author(s):  
Mohammad Shenagari ◽  
Ali Monfared ◽  
Hadise Eghtedari ◽  
Aydin Pourkazemi ◽  
Tolou Hasandokht ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Transplant ◽  
Virus Replication ◽  
Potential Risk ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Potential Risk Factors

scholarly journals Risk factors in the progression of BK virus-associated nephropathy in renal transplant recipients

2015 ◽  
Vol 30 (6) ◽  
pp. 865-872 ◽  
Author(s):  
Hae Min Lee ◽  
In-Ae Jang ◽  
Dongjae Lee ◽  
Eun Jin Kang ◽  
Bum Soon Choi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Transplant ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Prevalence of BK Virus among Iranian Renal Transplant Recipients: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 4 (4) ◽  
pp. 50-61
Author(s):  
Mohsen Ebrahimi ◽  
Alireza Mohebbi ◽  
Mohammad Mostakhdem Hashemi ◽  
Mobina Ashrafi Shahmirzadi ◽  
◽  
...  
Keyword(s):  
Systematic Review ◽  
Renal Transplant ◽  
Meta Analysis ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

BK Virus Nephropathy in Renal Transplant Recipients in Kuwait: A Preliminary Report

2005 ◽  
Vol 37 (7) ◽  
pp. 3048-3050 ◽  
Author(s):  
M.R.N. Nampoory ◽  
K.V. Johny ◽  
A. Pacsa ◽  
P.M. Nair ◽  
T. Said ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Preliminary Report ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Bk Virus Nephropathy

Diagnosis of Polyoma Virus Infection In Renal Transplant Recipients

1999 ◽  
Vol 5 (S2) ◽  
pp. 1166-1167
Author(s):  
J. A. C. King ◽  
D. N. Howell ◽  
J. A. Tucker ◽  
R. P. Lowry
Keyword(s):  
Renal Transplant ◽  
Virus Infection ◽  
Renal Transplant Patient ◽  
Bk Virus ◽  
Polyoma Virus ◽  
Immunosuppressed Patient ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Immunosuppressed Patients ◽  
Cadaver Kidney

BK polyoma virus is a 40-45 nm DNA virus that was first identified in the urine of an immunosuppressed patient in 1971. BK virus infection often occurs in childhood and is subclinical. The majority of adults have antibodies to the virus. Asymptomatic viruria, ureteral ulceration, and ureteral stenosis have been described with infection in immunosuppressed patients. Renal graft dysfunction and interstitial nephritis have been associated with BK virus. Differentiation between rejection and infection is important. We report a case of a renal transplant patient with BK polyoma virus infection. This case illustrates the variety of methods that can be used for identification of BK polyoma virus.The patient, a 52 year old female, presented with an asymptomatic rise in serum creatinine (1.4 to 2.1 mg/dl). Her past medical history was significant for a cadaver kidney transplant two years prior for polycystic kidney disease.

Sign in / Sign up

Export Citation Format

Share Document