Murine Gammaherpesvirus 68 Open Reading Frame 11 Encodes a Nonessential Virion Component
2005 ◽
Vol 79
(5)
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pp. 3163-3168
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Keyword(s):
ABSTRACT Open reading frame 11 (ORF11) is a conserved gammaherpesvirus gene that remains undefined. We identified the product of murine gammaherpesvirus 68 (MHV-68) ORF11, p43, as a virion component with a predominantly perinuclear distribution in infected cells. MHV-68 lacking p43 grew normally in vitro but showed reduced lytic replication in vivo and a delay in seeding to the spleen. Subsequent latency amplification was normal. Thus, MHV-68 ORF11 encoded a virion component that was important for in vivo lytic replication but dispensable for the establishment of latency.
2012 ◽
Vol 93
(5)
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pp. 1076-1080
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2004 ◽
Vol 78
(10)
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pp. 5103-5112
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2005 ◽
Vol 86
(4)
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pp. 919-928
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1998 ◽
Vol 79
(1)
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pp. 149-153
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2003 ◽
Vol 77
(4)
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pp. 2410-2417
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