scholarly journals Cross-Neutralization of Emerging SARS-CoV-2 Variants of Concern by Antibodies Targeting Distinct Epitopes on Spike

mBio ◽  
2021 ◽  
Author(s):  
Siriruk Changrob ◽  
Yanbin Fu ◽  
Jenna J. Guthmiller ◽  
Peter J. Halfmann ◽  
Lei Li ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
B Cells ◽  
Memory B Cells ◽  
Human Monoclonal Antibodies ◽  
Terminal Domain ◽  
Cross Neutralization ◽  
Pandemic Wave

We describe the binding and neutralization properties of a new set of human monoclonal antibodies derived from memory B cells of 10 coronavirus disease 2019 (COVID-19) convalescent donors in the first pandemic wave of prototype SARS-CoV-2. There were 12 antibodies targeting distinct epitopes on spike, including two sites on the RBD and one on the N-terminal domain (NTD), that displayed cross-neutralization of VOCs, for which distinct antibody targets could neutralize discrete variants.

scholarly journals Human monoclonal antibodies by immortalization of memory B cells

2007 ◽  
Vol 18 (6) ◽  
pp. 523-528 ◽  
Author(s):  
Antonio Lanzavecchia ◽  
Davide Corti ◽  
Federica Sallusto
Keyword(s):  
Monoclonal Antibodies ◽  
B Cells ◽  
Memory B Cells ◽  
Human Monoclonal Antibodies

scholarly journals Human Monoclonal Antibodies Derived From Memory B Cells Following Live Attenuated Dengue Virus Vaccination or Natural Infection Exhibit Similar Characteristics

2013 ◽  
Vol 207 (12) ◽  
pp. 1898-1908 ◽  
Author(s):  
Scott A. Smith ◽  
Ruklanthi de Alwis ◽  
Nurgun Kose ◽  
Anna P. Durbin ◽  
Stephen S. Whitehead ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
B Cells ◽  
Dengue Virus ◽  
Natural Infection ◽  
Memory B Cells ◽  
Human Monoclonal Antibodies ◽  
Virus Vaccination

scholarly journals Analysis of Human Monoclonal Antibodies Generated by Dengue Virus-Specific Memory B Cells

2012 ◽  
Vol 25 (5) ◽  
pp. 348-359 ◽  
Author(s):  
Heather Friberg ◽  
Smita Jaiswal ◽  
Kim West ◽  
Marvin O'Ketch ◽  
Alan L. Rothman ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
B Cells ◽  
Dengue Virus ◽  
Memory B Cells ◽  
Human Monoclonal Antibodies ◽  
Specific Memory

scholarly journals An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus

2004 ◽  
Vol 10 (8) ◽  
pp. 871-875 ◽  
Author(s):  
Elisabetta Traggiai ◽  
Stephan Becker ◽  
Kanta Subbarao ◽  
Larissa Kolesnikova ◽  
Yasushi Uematsu ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
B Cells ◽  
Efficient Method ◽  
Memory B Cells ◽  
Sars Coronavirus ◽  
Human Monoclonal Antibodies ◽  
Potent Neutralization
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