Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells
Keyword(s):
Mouse 3T3 cells were transformed with an antisense c-fos gene fused to a mouse mammary tumor virus promoter. In transformants that integrated a large number of antisense c-fos sequences, the usual large increase in c-fos mRNA and protein following stimulation of quiescent cells by platelet-derived growth factor was blocked in the presence of dexamethasone. These cells subsequently also failed to show the stimulation of DNA synthesis normally induced by platelet-derived growth factor. Appropriate expression of c-fos appears to be a prerequisite for reentry of quiescent cells into the cell cycle.
1987 ◽
Vol 7
(2)
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pp. 639-649
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1995 ◽
Vol 69
(8)
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pp. 4717-4726
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1994 ◽
Vol 205
(3)
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pp. 236-242
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Cyclic AMP suppresses expression of v-rasH oncogene linked to the mouse mammary tumor virus promoter
1986 ◽
Vol 134
(1)
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pp. 436-442
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Keyword(s):
2008 ◽
Vol 377
(4)
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pp. 1144-1160
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