Multiple Positive and Negative 5′ Regulatory Elements Control the Cell-Type-Specific Expression of the Embryonic Skeletal Myosin Heavy-Chain Gene:

1988 ◽  
Vol 8 (2) ◽  
pp. 1010-1010
Keyword(s):  
Heavy Chain ◽  
Regulatory Elements ◽  
Chain Gene ◽  
Cell Type ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Specific Expression ◽  
Skeletal Myosin ◽  
Cell Type Specific Expression ◽  
Cell Type Specific

Viral Strategies for Targeting the Central and Peripheral Nervous Systems

2018 ◽  
Vol 41 (1) ◽  
pp. 323-348 ◽  
Author(s):  
Claire N. Bedbrook ◽  
Benjamin E. Deverman ◽  
Viviana Gradinaru
Keyword(s):  
Nervous System ◽  
Regulatory Elements ◽  
Specific Cell ◽  
Cell Type ◽  
Specific Expression ◽  
Recombinant Viruses ◽  
Neuronal Populations ◽  
Neuroscience Research ◽  
Cell Type Specific Expression ◽  
Cell Type Specific

Recombinant viruses allow for targeted transgene expression in specific cell populations throughout the nervous system. The adeno-associated virus (AAV) is among the most commonly used viruses for neuroscience research. Recombinant AAVs (rAAVs) are highly versatile and can package most cargo composed of desired genes within the capsid's ∼5-kb carrying capacity. Numerous regulatory elements and intersectional strategies have been validated in rAAVs to enable cell type–specific expression. rAAVs can be delivered to specific neuronal populations or globally throughout the animal. The AAV capsids have natural cell type or tissue tropism and trafficking that can be modified for increased specificity. Here, we describe recently engineered AAV capsids and associated cargo that have extended the utility of AAVs in targeting molecularly defined neurons throughout the nervous system, which will further facilitate neuronal circuit interrogation and discovery.

scholarly journals Organization of the human skeletal myosin heavy chain gene cluster.

1992 ◽  
Vol 89 (24) ◽  
pp. 12078-12082 ◽  
Author(s):  
S. J. Yoon ◽  
S. H. Seiler ◽  
R. Kucherlapati ◽  
L. Leinwand
Keyword(s):  
Myosin Heavy Chain ◽  
Gene Cluster ◽  
Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Skeletal Myosin

scholarly journals Smooth Muscle–Specific Expression of the Smooth Muscle Myosin Heavy Chain Gene in Transgenic Mice Requires 5′-Flanking and First Intronic DNA Sequence

1998 ◽  
Vol 82 (8) ◽  
pp. 908-917 ◽  
Author(s):  
Cort S. Madsen ◽  
Christopher P. Regan ◽  
Jill E. Hungerford ◽  
Sheryl L. White ◽  
Ichiro Manabe ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Transgenic Mice ◽  
Myosin Heavy Chain ◽  
Dna Sequence ◽  
Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Specific Expression ◽  
Muscle Myosin

Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro

Cell ◽  
1987 ◽  
Vol 49 (1) ◽  
pp. 121-129 ◽  
Author(s):  
André Weydert ◽  
Paul Barton ◽  
A.John Harris ◽  
Christian Pinset ◽  
Margaret Buckingham
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Developmental Pattern ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Skeletal Myosin ◽  
Gene Transcripts
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