We have constructed regional structural transects across the Wichita Uplift and adjacent Anadarko Basin to show the relationship between thick-skinned basement-involved structures and thin-skinned detached fold-thrust structures. Slip from the basement-involved structures in the Wichita Uplift is transferred along two major detachments into the Anadarko Basin. Our interpretation is that along the northwestern margin, the Wichita Uplift is marked by a zone of frontal imbricates forming a triangular wedge with most of the slip dissipated along the Wichita front. Paleozoic units show tight folding with overturned beds in the frontal zone. The uplift is episodic as indicated by the truncation of major faults along unconformities and their subsequent reactivation. In contrast, along the southeast margin, a significant part of the slip is transferred into structures in the Anadarko Basin. These structures are tight faulted-detachment folds that formed above a major detachment within the Springer Shale, cored by broader structures detaching at the base of the Arbuckle Group. Examples include the Carter-Knox, Cement-Chickasha, and Cruce structures. Oblique faults with normal and strike-slip components cut some of these structures, resulting in more complex geometries. We propose that pre-existing normal faults of Precambrian-Cambrian age were either reactivated along the Wichita Uplift, or controlled the location of the Pennsylvanian age structures in the Anadarko Basin. Progressive rotation of regional stresses from northeast-southwest to a more east-northeast-west-southwest direction during the Pennsylvanian impacted the tectonic history of the area. We used 2D and 3D seismic, well log data, and surface geology were used to evaluate the structural styles and tectonic evolution of the Wichita Uplift and the Anadarko Basin.