Preferential Solvation of Pomalidomide, an Immunomodulatory Drug, in Some Biocompatible Binary Mixed Solvents at 298.15 K

2021 ◽  
Vol 95 (12) ◽  
pp. 2432-2443
Author(s):  
Mohsen Padervand ◽  
Fariba Teymoorzadeh ◽  
Abolghasem Beheshti ◽  
Mohammad Kazem Bahrami
Keyword(s):  
Preferential Solvation ◽  
Mixed Solvents ◽  
Immunomodulatory Drug

Preferential Solvation of Ions in Mixed Solvents

1986 ◽  
Vol 150 (1) ◽  
pp. 113-122 ◽  
Author(s):  
Dip Singh Gill ◽  
Suvarcha Chauhan ◽  
Mohinder Singh Chauhan
Keyword(s):  
Preferential Solvation ◽  
Mixed Solvents ◽  
Solvation Of Ions

scholarly journals Solvation in pure and mixed solvents: Some recent developments

2007 ◽  
Vol 79 (6) ◽  
pp. 1135-1151 ◽  
Author(s):  
Omar A. El Seoud
Keyword(s):  
Hydrogen Bonding ◽  
Hydrophobic Interactions ◽  
Preferential Solvation ◽  
Mixed Solvents ◽  
Effect Of Temperature ◽  
Binary Solvent ◽  
Solvent Mixtures ◽  
Dispersion Interactions ◽  
Binary Solvent Mixtures ◽  
Recent Developments

The effect of solvents on the spectra, absorption, or emission of substances is called solvatochromism; it is due to solute/solvent nonspecific and specific interactions, including dipole/dipole, dipole-induced/dipole, dispersion interactions, and hydrogen bonding. Thermo-solvatochromism refers to the effect of temperature on solvatochromism. The molecular structure of certain substances, polarity probes, make them particularly sensitive to these interactions; their solutions in different solvents have distinct and vivid colors. The study of both phenomena sheds light on the relative importance of the solvation mechanisms. This account focuses on recent developments in solvation in pure and binary solvent mixtures. The former has been quantitatively analyzed in terms of a multiparameter equation, modified to include the lipophilicity of the solvent. Solvation in binary solvent mixtures is complex because of the phenomenon of "preferential solvation" of the probe by one component of the mixture. A recently introduced solvent exchange model allows calculation of the composition of the probe solvation shell, relative to that of bulk medium. This model is based on the presence of the organic solvent (S), water (W), and a 1:1 hydrogen-bonded species (S-W). Solvation by the latter is more efficient than by its precursor solvents, due to probe/solvent hydrogen-bonding and hydrophobic interactions. Dimethylsulfoxide (DMSO) is an exception, because the strong DMSO/W interactions probably deactivate the latter species toward solvation. The relevance of the results obtained to kinetics of reactions is briefly discussed by addressing temperature-induced desolvation of the species involved (reactants and activated complexes) and the complex dependence of kinetic data (observed rate constants and activation parameters) in binary solvent mixtures on medium composition.

Chiral Solvation as a Means to Quantitatively Characterize Preferential Solvation of a Helical Polymer in Mixed Solvents

1997 ◽  
Vol 119 (30) ◽  
pp. 6991-6995 ◽  
Author(s):  
Chetan A. Khatri ◽  
Yevgenia Pavlova ◽  
Mark M. Green ◽  
Herbert Morawetz
Keyword(s):  
Preferential Solvation ◽  
Mixed Solvents ◽  
Helical Polymer

Preferential Solvation of Ions in Mixed Solvents II

1983 ◽  
Vol 136 (136) ◽  
pp. 117-122 ◽  
Author(s):  
Dip Singh Gill ◽  
Reeta Nording
Keyword(s):  
Preferential Solvation ◽  
Mixed Solvents ◽  
Solvation Of Ions

Preferential Solvation and Hydrogen Bonding in Mixed Solvents

2008 ◽  
Vol 120 (33) ◽  
pp. 6371-6373 ◽  
Author(s):  
Joanne L. Cook ◽  
Christopher A. Hunter ◽  
Caroline M. R. Low ◽  
Alejandro Perez-Velasco ◽  
Jeremy G. Vinter
Keyword(s):  
Hydrogen Bonding ◽  
Preferential Solvation ◽  
Mixed Solvents

Preferential Solvation of Ions in Mixed Solvents

1984 ◽  
Vol 140 (2) ◽  
pp. 139-148 ◽  
Author(s):  
Dip Singh Gill ◽  
Mohinder Singh Chauhan
Keyword(s):  
Preferential Solvation ◽  
Mixed Solvents ◽  
Solvation Of Ions

scholarly journals Study of solute-solvent interactions of nicotinic acid and benzoic acid in methanol and its binary solvent systems

2008 ◽  
Vol 73 (12) ◽  
pp. 1235-1246 ◽  
Author(s):  
Nath Roy ◽  
Lovely Sarkar ◽  
Kumar Sarkar
Keyword(s):  
Benzoic Acid ◽  
Nicotinic Acid ◽  
Preferential Solvation ◽  
Mixed Solvents ◽  
Relative Viscosity ◽  
State Theory ◽  
Binary Solvent ◽  
Molar Volumes ◽  
Pure Methanol ◽  
B Coefficients

The apparent molar volumes, ?V, and viscosity B-coefficients, B, for nicotinic acid (NA) and benzoic acid (BA) in mixed solvents containing 10, 20, 30 mass % of n-amyl alcohol (n-AmOH) or isoamyl alcohol (i-AmOH) in methanol and in pure methanol (MeOH) were determined from the solution density and viscosity measurements at 298.15 K as function of concentrations of NA and BA. These results were, in conjunction with the results obtained in pure methanol, used to deduce the partial molar volumes of transfer, 0 ??V , and viscosity B-coefficients of transfer, ?B, for NA and BA from methanol to different mixed methanol solvents, in order to rationalize various interactions in the ternary solutions. An increase in the transfer properties of NA and BA with increasing mass % of n-AmOH and i-AmOH in methanol was observed and explained by the effect of structural changes and preferential solvation. Also, the free energies of viscous flow, ? 0? 1 ? and ? 0? ?2 , per mole of solvent and solute, respectively, were calculated and analyzed on the basis of the transition state theory of relative viscosity.

Sign in / Sign up

Export Citation Format

Share Document