Preparation of N-protected α-amino alcohols by acetoxyborohydride reduction of N-protected α-amino acid esters
1990 ◽
Vol 55
(3)
◽
pp. 761-765
◽
Keyword(s):
N-Protected α-amino alcohols were prepared by reduction of N-protected α-amino acid esters by sodium acetoxyborohydride in dioxane at elevated temperature. The reductions proceed with excellent yields and without racemisation. Reduction of the carbamate protecting groups was not observed.