Bridged bis-Tröger’s base molecular tweezers as new cavitand family

2009 ◽  
Vol 74 (7-8) ◽  
pp. 1091-1099 ◽  
Author(s):  
Martin Havlík ◽  
Václav Parchaňský ◽  
Petr Bouř ◽  
Vladimír Král ◽  
Bohumil Dolensky
Keyword(s):  
Molecular Tweezers ◽  
Troger's Base

New molecular tweezers based on bis-Tröger’s base with methoxycarbonyl groups on its pincers was prepared. These groups were converted into hydroxymethyl groups, which were interconnected by a linker to give the bridged molecular tweezers, a cavitand. The cavitand was studied and its ability to bind nitrobenzene was compared with similar bis-Tröger’s base molecular tweezers.

A New Bis-Tröger's Base: Synthesis, Spectroscopy, Crystal Structure and Isomerization

2006 ◽  
Vol 71 (9) ◽  
pp. 1278-1302 ◽  
Author(s):  
Martin Valík ◽  
Pavel Matějka ◽  
Eberhardt Herdtweck ◽  
Vladimír Král ◽  
Bohumil Dolensky
Keyword(s):  
Crystal Structure ◽  
Spectroscopic Data ◽  
The Other ◽  
X Ray Diffraction ◽  
One Pot ◽  
Molecular Tweezers ◽  
X Ray ◽  
Troger's Base ◽  
Ir And Raman ◽  
C Nmr

A new bis-Tröger's base was prepared from a tetraamine precursor as a mixture of two diastereoisomers. One of the isomers has a chair-like geometry, and the other possesses a boat-like geometry, embodying molecular tweezers. A one-pot preparation of bis-TB isomers and their interconversion under acid conditions was also studied. Structures of both isomers were confirmed by single-crystal X-ray diffraction. Extensive spectroscopic data, including 1H and 13C NMR, IR and Raman spectra of the isomers, are given.

New Chiral Molecular Tweezers with a Bis-Tröger's Base Skeleton†

2001 ◽  
Vol 66 (5) ◽  
pp. 1607-1611 ◽  
Author(s):  
Carmen Pardo ◽  
Esther Sesmilo ◽  
Enrique Gutiérrez-Puebla ◽  
Angeles Monge ◽  
José Elguero ◽  
...  
Keyword(s):  
Molecular Tweezers ◽  
Troger's Base

Synthesis of new chiral molecular tweezers with a tris-Tröger's base skeleton

2004 ◽  
Vol 14 (6) ◽  
pp. 235-237 ◽  
Author(s):  
Thierry Mas ◽  
Carmen Pardo ◽  
José Elguero
Keyword(s):  
Molecular Tweezers ◽  
Troger's Base

scholarly journals New Molecular Tweezers with a Bis-Tröger's Base Skeleton.

2001 ◽  
Vol 66 (11) ◽  
pp. 4104-4104 ◽  
Author(s):  
Carmen Pardo ◽  
Esther Sesmilo ◽  
Enrique Gutiérrez-Puebla ◽  
Angeles Monge ◽  
José Elguero ◽  
...  
Keyword(s):  
Molecular Tweezers ◽  
Troger's Base

Synthesis of Halogen Substituted Analogues of Tröger's Base

Synthesis ◽  
2001 ◽  
Vol 2001 (12) ◽  
pp. 1873-1877 ◽  
Author(s):  
Jacob Jensen ◽  
Kenneth Wärnmark
Keyword(s):  
Troger's Base

scholarly journals Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Annika Meiners ◽  
Sandra Bäcker ◽  
Inesa Hadrović ◽  
Christian Heid ◽  
Christine Beuck ◽  
...  
Keyword(s):  
Nuclear Export ◽  
Rational Design ◽  
Nuclear Export Signal ◽  
Signal Interference ◽  
Receptor Interaction ◽  
Dual Function ◽  
Experimental Proof ◽  
Molecular Tweezers ◽  
Recognition Element ◽  
Dynamics Simulations

AbstractSurvivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. This protein–protein interaction represents an attractive target in cancer research and therapy. Here, we report a sophisticated strategy addressing Survivin’s nuclear export signal (NES), the binding site of CRM1, with advanced supramolecular tweezers for lysine and arginine. These were covalently connected to small peptides resembling the natural, self-complementary dimer interface which largely overlaps with the NES. Several biochemical methods demonstrated sequence-selective NES recognition and interference with the critical receptor interaction. These data were strongly supported by molecular dynamics simulations and multiscale computational studies. Rational design of lysine tweezers equipped with a peptidic recognition element thus allowed to address a previously unapproachable protein surface area. As an experimental proof-of-principle for specific transport signal interference, this concept should be transferable to any protein epitope with a flanking well-accessible lysine.

Enhanced molecular selectivity and plasticization resistance in ring-opened Tröger's base polymer membranes

2021 ◽  
pp. 119399
Author(s):  
Lei Wu ◽  
Xiuling Chen ◽  
Zhiguang Zhang ◽  
Shan Xu ◽  
Canghai Ma ◽  
...  
Keyword(s):  
Polymer Membranes ◽  
Troger's Base ◽  
Base Polymer

scholarly journals Sizable iodine uptake of porous copolymer networks bearing Tröger's base units

Polymer ◽  
2021 ◽  
pp. 123996
Author(s):  
Suchetha Shetty ◽  
Noorullah Baig ◽  
Moustafa Sherief Moustafa ◽  
Saleh Al-Mousawi ◽  
Bassam Alameddine
Keyword(s):  
Iodine Uptake ◽  
Troger's Base ◽  
Porous Copolymer ◽  
Base Units
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