scholarly journals SAT0304 Stimulatory and inhibitory killer immunoglobulin-like receptors on natural killer T (NKT) cells in patients with systemic lupus erythematosus (SLE): relation to disease activity

2017 ◽  
Author(s):  
SI Nasef ◽  
AM Asker ◽  
HH Omar ◽  
HM Hassoba
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Natural Killer ◽  
Lupus Erythematosus ◽  
Nkt Cells ◽  
Systemic Lupus ◽  
Natural Killer T

scholarly journals Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Yi-Ping Chuang ◽  
Chih-Hung Wang ◽  
Ning-Chi Wang ◽  
Deh-Ming Chang ◽  
Huey-Kang Sytwu
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Natural Killer ◽  
Lupus Erythematosus ◽  
Systemic Disease ◽  
Clinical Manifestations ◽  
Peripheral Tolerance ◽  
Inkt Cells ◽  
Systemic Lupus ◽  
Invariant Natural Killer ◽  
Natural Killer T

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with complex immunological and clinical manifestations. Multiple organ failure in SLE can be caused by immune dysfunction and deposition of autoantibodies. Studies of SLE-susceptible loci and the cellular and humoral immune responses reveal variable aberrations associated with this systemic disease. Invariant natural killer T (iNKT) cells are a unique subset of lymphocytes that control peripheral tolerance. Mounting evidence showing reductions in the proportion and activity of iNKT cells in SLE patients suggests the suppressive role of iNKT cells. Studies using murine lupus models demonstrate that iNKT cells participate in SLE progression by sensing apoptotic cells, regulating immunoglobulin production, and altering the cytokine profile upon activation. However, the dichotomy of iNKT cell actions in murine models implies complicated interactions within the body's milieu. Therefore, application of potential therapy for SLE using glycolipids to regulate iNKT cells should be undertaken cautiously.

scholarly journals Natural killer T cells in families of patients with systemic lupus erythematosus: Their possible role in regulation of IGG production

2006 ◽  
Vol 56 (1) ◽  
pp. 303-310 ◽  
Author(s):  
Matthew R. J. Green ◽  
Amy S. M. Kennell ◽  
Maggie J. Larche ◽  
Martin H. Seifert ◽  
David A. Isenberg ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cells ◽  
Natural Killer ◽  
Lupus Erythematosus ◽  
Natural Killer T Cells ◽  
Systemic Lupus ◽  
Killer T Cells ◽  
Natural Killer T
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