scholarly journals AB0530 CHARACTERISTICS AND MEDIUM-TERM OUTCOMES OF TAKAYASU ARTERITIS–RELATED RENAL ARTERY STENOSIS: ANALYSIS OF A LARGE CHINESE COHORT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1562.2-1562
Author(s):  
Y. Sun ◽  
X. Dai ◽  
P. LV ◽  
Z. Dong ◽  
J. Lin ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Takayasu Arteritis ◽  
Adverse Outcomes ◽  
Artery Stenosis ◽  
Left Renal Artery ◽  
Preoperative Treatment ◽  
Medium Term ◽  
Chinese Cohort

Background:The incidence of renal artery stenosis in Takayasu arteritis (TA) was 20%–60% according to previous reports. The specific characteristics of patients with TA-related renal artery stenosis and the effect of revascularization procedures on prognosis have not been fully investigated.Objectives:To investigate the characteristics of patients with TA-related renal artery stenosis and identify the predictors of medium-term adverse outcomes.Methods:Data for 567 patients registered in a large prospective observational cohort-the East China Takayasu arteritis cohort-up to April 30, 2019, were retrospectively analyzed.Results:Renal artery stenosis was confirmed in 172/567 (30.34%) patients, with left renal artery involvement seen in 73/172 (42.44%) patients. Renal insufficiency at presentation (HR = 2.37, 95% CI: 1.76-15.83, p = 0.03), bilateral renal artery involvement (HR = 6.95, 95% CI: 1.18-21.55, p = 0.01), and severe (>75%) stenosis (HR = 4.75, 95% CI 1.08-11.33, p = 0.05) were predictors of adverse outcomes. Revascularization was performed for 46/172 (26.74%) patients. Patients without preoperative treatment had higher rate of restenosis (44.44% vs. 15.79%, p < 0.01) and hypertension deterioration (25.93% vs. 10.53%, p < 0.01) after the procedure. Non-receipt of preoperative treatment (HR = 6.5, 95% CI: 1.77-32.98, p = 0.04) and active disease at revascularization (HR = 4.21, 95% CI 2.01-21.44, p = 0.04) were independent predictors of adverse outcomes after revascularization.Conclusion:Patients with uncontrolled or worsening hypertension or/and renal function may benefit from revascularization. Those who have received preoperative treatment may have more favorable revascularization outcomes. Prognosis appears to be poorer for patients with renal insufficiency at presentation, bilateral artery involvement, and severe stenosis.References:[1]Watanabe Y, Miyata T, Tanemoto K. Current clinical features of new patients with Takayasu arteritis observed from a cross-country research in Japan: age and sex specificity. Circulation 2015; 132: 1701-9.[2]Peng M, Jiang XJ, Dong H, et al. Etiology of renal artery stenosis in 2047 patients: a single-center retrospective analysis during a 15-year period in China. J Hum Hypertens 2016; 30: 124-8Disclosure of Interests:None declared

Characteristics and Medium-term Outcomes of Takayasu Arteritis–related Renal Artery Stenosis: Analysis of a Large Chinese Cohort

2020 ◽  
Vol 48 (1) ◽  
pp. 87-93
Author(s):  
Ying Sun ◽  
Xiaomin Dai ◽  
Peng Lv ◽  
Zhihui Dong ◽  
Lingying Ma ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Takayasu Arteritis ◽  
Adverse Outcomes ◽  
Artery Stenosis ◽  
Preoperative Treatment ◽  
Medium Term ◽  
Severe Stenosis ◽  
Bilateral Renal Artery

Objective.To investigate the characteristics of patients with Takayasu arteritis (TA)-related renal artery stenosis and identify the predictors of medium-term adverse outcomes.Methods.Data for 567 patients registered in the East China Takayasu arteritis cohort, a large prospective observational cohort, up to April 30, 2019, were retrospectively analyzed.Results.Renal artery stenosis was confirmed in 172/567 (30.34%) patients, with left renal artery involvement seen in 73/172 (42.44%) patients. Renal insufficiency at presentation (HR 2.37, 95% CI 1.76–15.83, P = 0.03), bilateral renal artery involvement (HR 6.95, 95% CI 1.18–21.55, P = 0.01), and severe stenosis (> 75%; HR 4.75, 95% CI 1.08–11.33, P = 0.05) were predictors of adverse outcomes. A matrix model constructed using 3 variables (renal function, stenosis severity, and bilateral renal artery involvement) could identify 3 risk groups. Revascularization was performed for 46 out of 172 (26.74%) patients. Patients without preoperative treatment had higher rate of restenosis (41.46% vs 16.67%, P < 0.01) and worsening hypertension (25.93% vs. 10.53%, P < 0.01) after the procedure. Nonreceipt of preoperative treatment (HR 6.5, 95% CI 1.77–32.98, P = 0.04) and active disease at revascularization (HR 4.21, 95% CI 2.01–21.44, P = 0.04) were independent predictors of adverse outcomes after revascularization.Conclusion.Patients with TA-associated renal artery stenosis and uncontrolled or worsening hypertension or/and renal function may benefit from revascularization. Those who have received preoperative treatment may have more favorable revascularization outcomes. Prognosis appears to be poorer for patients with renal insufficiency at presentation, bilateral artery involvement, and severe stenosis.

Traumatic Left Renal Artery Stenosis Managed with Splenorenal Bypass

1990 ◽  
Vol 30 (12) ◽  
pp. 1594-1596 ◽  
Author(s):  
GARY W. BARONE ◽  
MARK B. KAHN ◽  
JAMES M. COOK ◽  
BERNARD W. THOMPSON ◽  
ROBERT W. BARNES ◽  
...  
Keyword(s):  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Artery Stenosis ◽  
Left Renal Artery

scholarly journals Non-invasive investigations of potential renal artery stenosis in renal insufficiency

2010 ◽  
Vol 25 (11) ◽  
pp. 3607-3614 ◽  
Author(s):  
P. Eriksson ◽  
A. A. Mohammed ◽  
J. De Geer ◽  
J. Kihlberg ◽  
A. Persson ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Artery Stenosis ◽  
Non Invasive

Captopril-Induced Functional Renal Insufficiency in Patients with Bilateral Renal-Artery Stenoses or Renal-Artery Stenosis in a Solitary Kidney

1983 ◽  
Vol 308 (7) ◽  
pp. 373-376 ◽  
Author(s):  
Donald E. Hricik ◽  
Philip J. Browning ◽  
Richard Kopelman ◽  
Warren E. Goorno ◽  
Nicolaos E. Madias ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Solitary Kidney ◽  
Artery Stenosis ◽  
Bilateral Renal Artery ◽  
Renal Artery Stenoses

scholarly journals Renal artery stenosis of atherosclerotic etiology – the single kidney surgical recurrence 12 years after nephrectomy

2016 ◽  
Vol 63 (3) ◽  
pp. 251-254
Author(s):  
Maria Daniela Tănăsescu ◽  
◽  
Marcel Pălămar ◽  
Mihai Ovidiu Comşa ◽  
Alexandru Mincă ◽  
...  
Keyword(s):  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Left Kidney ◽  
Secondary Hypertension ◽  
Artery Stenosis ◽  
The Other ◽  
Left Renal Artery ◽  
Arterial Blood ◽  
The Moment ◽  
The Right

Objectives. Renal artery stenosis, as main cause of renovascular secondary hypertension, is mainly caused by atherosclerosis of large vessels and is clinically characterized by resistant or malignant hypertension, impacting the kidney function to various degrees. The present article brings into attention the case of a patient which developed renal artery stenosis on the left kidney, the same condition occurring 12 years later on the right kidney. Material and method. Our patient was initially diagnosed at the age of 48 with complete occlusion of the left renal artery, for which left nephrectomy was performed, while the right artery was normal. Twelve years later she presents with renal artery stenosis on the right kidney, which is treat by stent-angioplasty. Results. After surgery, the patient’s evolution was positive, with amelioration of the laboratory values, in parallel to the arterial blood pressure. Discussions. The probability that, in the moment of diagnosis of renal artery stenosis with progressive evolution to occlusion caused by atherosclerosis, the other artery would be normal, both seen by ultrasonography and angiography, while years later to develop stenosis, is minimal. Up to present, the literature holds little evidence of such similar cases. Conclusions. In the particular case of patients that were diagnosed with severe renal artery stenosis of atherosclerotic origin and had only one of the arteries affected, it is necessary to keep a permanent monitoring, justified by the risk of development of the same pathology to the other artery

Sign in / Sign up

Export Citation Format

Share Document