scholarly journals Acute anterior uveitis, ankylosing spondylitis, back pain, and HLA-B27.

1984 ◽  
Vol 68 (10) ◽  
pp. 741-745 ◽  
Author(s):  
A. B. Beckingsale ◽  
J. Davies ◽  
J. M. Gibson ◽  
A. R. Rosenthal
Keyword(s):  
Back Pain ◽  
Ankylosing Spondylitis ◽  
Anterior Uveitis ◽  
Hla B27 ◽  
Acute Anterior Uveitis

scholarly journals Is a positive family history of spondyloarthritis relevant for diagnosing axial spondyloarthritis once HLA-B27 status is known?

Rheumatology ◽  
2019 ◽  
Vol 58 (9) ◽  
pp. 1649-1654 ◽  
Author(s):  
Miranda van Lunteren ◽  
Désirée van der Heijde ◽  
Alexandre Sepriano ◽  
Inger J Berg ◽  
Maxime Dougados ◽  
...  
Keyword(s):  
Back Pain ◽  
Family History ◽  
Anterior Uveitis ◽  
Chronic Back Pain ◽  
Axial Spondyloarthritis ◽  
Positive Family History ◽  
Hla B27 ◽  
Acute Anterior Uveitis ◽  
Negative Results ◽  
History Of

Abstract Objectives A positive family history (PFH) of spondyloarthritis, in particular a PFH of AS or acute anterior uveitis, is associated with HLA-B27 carriership in chronic back pain patients. As it is unknown, the study aimed to investigate if a PFH contributes to diagnosing axial spondyloarthritis (axSpA) once HLA-B27 status is known. Methods In axSpA-suspected patients from the Assessment of SpondyloArthritis international Society (ASAS), DEvenir des Spondyloarthropathies Indifférenciéés Récentes (DESIR) and SPondyloArthritis Caught Early (SPACE) cohorts, logistic regression analyses were performed with HLA-B27 status and PFH according to the ASAS definition (ASAS-PFH) as determinants and clinical axSpA diagnosis as outcome at baseline. Analyses were repeated with a PFH of AS or acute anterior uveitis. Results In total, 1818 patients suspected of axSpA were analysed (ASAS n = 594, DESIR n = 647, and SPACE n = 577). In patients from the ASAS, DESIR and SPACE cohorts, respectively 23%, 39% and 38% had an ASAS-PFH, 52%, 58% and 43% were HLA-B27 positive, and 62%, 47% and 54% were diagnosed with axSpA. HLA-B27 was independently associated with an axSpA diagnosis in each cohort but an ASAS-PFH was not [ASAS cohort: HLA-B27 odds ratio (OR): 6.9 (95% CI: 4.7, 10.2), ASAS-PFH OR: 0.9 (95% CI: 0.6, 1.4); DESIR: HLA-B27 OR: 2.1 (95% CI: 1.5, 2.9), ASAS-PFH OR: 1.0 (95% CI 0.7, 1.3); SPACE: HLA-B27 OR: 10.4 (95% CI: 6.9, 15.7), ASAS-PFH OR: 1.0 (95% CI: 0.7, 1.5)]. Similar negative results were found for PFH of AS and acute anterior uveitis. Conclusion In three independent cohorts with different ethnical backgrounds, ASAS, DESIR and SPACE, a PFH was not associated independently of HLA-B27 with a diagnosis of axSpA. This indicates that in the vast majority of patients presenting with back pain, a PFH does not contribute to the likelihood of an axSpA diagnosis if HLA-B27 status is known.

The Association between Ankylosing Spondylitis, Acute Anterior Uveitis and HLA-B27: The Results of a Swiss Family Study

Rheumatology ◽  
1988 ◽  
Vol XXVII (suppl 2) ◽  
pp. 39-41 ◽  
Author(s):  
S. M. van der Linden ◽  
H. U. Rentsch ◽  
N. Gerber ◽  
A. Cats ◽  
H. A. Valkenburg
Keyword(s):  
Ankylosing Spondylitis ◽  
Anterior Uveitis ◽  
Family Study ◽  
Hla B27 ◽  
Acute Anterior Uveitis

scholarly journals Diagnosis of Ankylosing Spondylitis: Do not let the spine bites the eye

2021 ◽  
Vol 16 (2) ◽  
pp. 73-77
Author(s):  
Chia Chee Chew ◽  
Ju Juen Chin ◽  
Wan Hazabbah Wan Hitam ◽  
Mei Fong Chong ◽  
Liza-Sharmini Ahmad Tajudin
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Ankylosing Spondylitis ◽  
Young Adult ◽  
Anterior Uveitis ◽  
Case Series ◽  
Topical Steroids ◽  
Initial Symptom ◽  
Low Back ◽  
Acute Anterior Uveitis

Background: A diagnosis of ankylosing spondylitis (AS) is challenging and often delayed despitebpatients being symptomatic. Low back pain is the most common initial symptom, appearing in the second and third decades of life. Acute anterior uveitis (AAU) occurs much later in the course of the disease, often when the destruction of the spine is already debilitating. Objective: Here, we report three cases of AS that were diagnosed after the patients developed AAU. Methods: A case series illustrated AAU leading to the diagnosis of AS years after the initial episode of low back pain. A comparison of the clinical presentation, diagnosis, and outcomes was also illustrated. Result: We report three cases of acute anterior uveitis (AAU)-associated AS diagnosed only after many visits to the primary health care provider with the complaint of chronic low back pain. All three patients had irreversible radiological changes upon diagnosis of AS. The AAU resolved with topical steroids, and one patient developed cataract. Conclusion: A high index of suspicion of AS in a young adult with chronic back pain before the development of AAU may prevent further functional loss and provide a better prognosis. Diagnosis of AS following AAU is not only associated with dependency but also may rob the vision of a young adult.

scholarly journals Clinical features of HLA-B27-positive acute anterior uveitis with or without ankylosing spondylitis in a Chinese cohort

2017 ◽  
Vol 102 (2) ◽  
pp. 215-219 ◽  
Author(s):  
Peizeng Yang ◽  
Wenjuan Wan ◽  
Liping Du ◽  
Qingyun Zhou ◽  
Jian Qi ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features ◽  
Anterior Uveitis ◽  
Human Leucocyte Antigen ◽  
Visual Outcome ◽  
Secondary Glaucoma ◽  
Vascular Involvement ◽  
Hla B27 ◽  
Acute Anterior Uveitis ◽  
Complicated Cataract

AimsTo characterise the clinical features of human leucocyte antigen (HLA)-B27+acute anterior uveitis (AAU) patients with or without ankylosing spondylitis (AS) and investigate the retinal vascular involvement in these patients.MethodsA total of 1056 HLA-B27+ AAU patients (1525 eyes) were retrospectively studied from April 2008 to February 2016. Patients were divided into human leucocyte antigen (HLA)-B27+AS+ and HLA-B27+AS− group. Clinical features including the onset of uveitis, laterality, the age at first attack, clinical examinations, best corrected visual acuity (BCVA), abnormalities in fundus fluorescence angiography (FFA) and complications were determined and compared between these two groups.ResultsThere were 581 (55.0%) and 475 (45.0%) patients respectively classified into HLA-B27+AS+ and HLA-B27+AS− group. Males had a higher prevalence than females in the HLA-B27+AS+ group (75.2%) as compared with the HLA-B27+AS− group (51.8%, p<0.001). The HLA-B27+AS+ patients showed a higher percentage of bilateral/alternating involvement (47.3%) as compared with the HLA-B27+AS− group (36.6%, p=0.001). A higher percentage of fibrinous exudation, synechiae as well as complications including complicated cataract and secondary glaucoma were found in the HLA-B27+AS+ group as compared with the HLA-B27+AS− group. Worse visual outcome as indicated by a higher percentage of patients with BCVA <0.5 and with BCVA <0.05 was noted in the HLA-B27+AS+ group as compared with the HLA-B27+AS− group both before and after treatment. FFA showed mild capillary fluorescence leakage in the late phase with indistinctly defined margins on the peripheral retina in 39.3% of HLA-B27+ AAU patients. There was no difference concerning the retinal vascular involvement between these two groups.ConclusionsOur study confirmed that HLA-B27+AS+ patients show a higher percentage of males, more common bilateral involvement, a higher frequency of fibrinous exudates, synechiae and secondary glaucoma as compared with HLA-B27+AS− patients. Visual outcome was poorer, possibly due to the higher prevalence of complicated cataract in HLA-B27+AS+ patients. Retinal vascular involvement was not uncommon in HLA-B27+ AAU patients.

scholarly journals Assessment of Correlation Between HLA-B27 Associated Ankylosing Spondylitis With Acute Anterior Uveitis

2018 ◽  
Vol 5 (9) ◽  
pp. A785-787
Author(s):  
Sachin Sharma ◽  
C.V. Kulkarni ◽  
Ashok Yadav ◽  
Sweta Tripathi ◽  
Gaurav Shelgaonkar
Keyword(s):  
Ankylosing Spondylitis ◽  
Anterior Uveitis ◽  
Hla B27 ◽  
Acute Anterior Uveitis

TAP polymorphism is not associated with ankylosing spondylitis and complications with acute anterior uveitis in HLA-B27-positive Japanese

1998 ◽  
Vol 52 (5) ◽  
pp. 478-483 ◽  
Author(s):  
Y. Konno ◽  
J. Numaga ◽  
M. Mochizuki ◽  
H. Mitsui ◽  
R. Hirata ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Anterior Uveitis ◽  
Hla B27 ◽  
Acute Anterior Uveitis
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