Evidence of lower macular pigment optical density in chronic open angle glaucoma

Purpose. To investigate macular pigment optical density (MPOD) and its relationship with retinal thickness in primary open angle glaucoma (POAG) patients using the one-wavelength reflectometry method.Methods. A total of 30 eyes from 30 POAG patients (18 males and 12 females, mean age47.27±16.93) and 52 eyes from 52 controls (27 males and 25 females, mean age49.54±19.15) were included in this prospective, observational, case-control study. MPOD was measured in a 7-degree area using one-wavelength reflectometry method. Two parameters, max and mean optical density (OD), were used for analyses. Spectral-domain-optical coherence tomography was used to measure retinal thickness, including central retinal thickness (CRT), the macular ganglion cell complex (GCC), and the circumpapillary retinal nerve fiber layer (RNFL).Results. Both maxOD and meanOD were significantly reduced in POAG patients compared with normal subjects (P<0.001). GCC, CRT, and RNFL thicknesses were also significantly reduced in POAG patients (P<0.001). GCC thickness had a positive relationship with MPOD.Conclusions. MPOD within the 7-degree area was significantly lower in Chinese POAG patients than in control subjects, and GCC thickness was significantly and positively associated with MPOD. Whether the observed lower MPOD in POAG contributes to the disease process or is secondary to pathological changes caused by the disease (such as loss of ganglion cells) warrants further and longitudinal study.

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Macular pigment optical density change analysis in primary open-angle glaucoma and pseudoexfoliation glaucoma

International Ophthalmology ◽

10.1007/s10792-021-01784-3 ◽

2021 ◽

Author(s):

Cenk Zeki Fikret ◽

Nil Irem Ucgun

Keyword(s):

Optical Density ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Macular Pigment ◽

Density Change ◽

Open Angle ◽

Macular Pigment Optical Density ◽

Pseudoexfoliation Glaucoma ◽

Change Analysis ◽

Optical Density Change

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The role of the macular pigment optical density measurement in the diagnosis of eye diseases

Clinical ophthalmology ◽

10.21689/2311-7729-2016-16-4-197-200 ◽

2016 ◽

Vol 16 (4) ◽

pp. 197-200

Author(s):

E.N. Eskina ◽

◽

E.A. Egorov ◽

A.V. Belogurova ◽

А.А. Gvetadze ◽

...

Keyword(s):

Optical Density ◽

Density Measurement ◽

Macular Pigment ◽

Eye Diseases ◽

Macular Pigment Optical Density ◽

Optical Density Measurement

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Macular Pigment Optical Density and Photoreceptor Outer Segment Length as Predisease Biomarkers for Age-Related Macular Degeneration

Journal of Clinical Medicine ◽

10.3390/jcm9051347 ◽

2020 ◽

Vol 9 (5) ◽

pp. 1347 ◽

Cited By ~ 1

Author(s):

Norihiro Nagai ◽

Sakiko Minami ◽

Misa Suzuki ◽

Hajime Shinoda ◽

Toshihide Kurihara ◽

...

Keyword(s):

Macular Degeneration ◽

Optical Density ◽

Outer Segment ◽

Macular Pigment ◽

Age Related Macular Degeneration ◽

Segment Length ◽

Macular Pigment Optical Density ◽

Photoreceptor Outer Segment ◽

Age Related ◽

Fellow Eyes

To explore predisease biomarkers, which may help screen for the risk of age-related macular degeneration (AMD) at very early stages, macular pigment optical density (MPOD) and photoreceptor outer segment (PROS) length were analyzed. Thirty late AMD fellow eyes, which are at high risk and represent the predisease condition of AMD, were evaluated and compared with 30 age-matched control eyes without retinal diseases; there was no early AMD involvement in the AMD fellow eyes. MPOD was measured using MPS2® (M.E. Technica Co. Ltd., Tokyo, Japan), and PROS length was measured based on optical coherence tomography images. MPOD levels and PROS length in the AMD fellow eyes were significantly lower and shorter, respectively, than in control eyes. MPOD and PROS length were positively correlated in control eyes (R = 0.386; p = 0.035) but not in AMD fellow eyes. Twenty (67%) AMD fellow eyes met the criteria of MPOD < 0.65 and/or PROS length < 35 μm, while only five (17%) control eyes did. After adjusting for age and sex, AMD fellow eyes more frequently satisfied the definition (p < 0.001; 95% confidence interval, 3.50–60.4; odds ratio, 14.6). The combination of MPOD and PROS length may be a useful biomarker for screening predisease AMD patients, although further studies are required in this regard.

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Macular pigment optical density in central serous chorioretinopathy

Therapeutic Advances in Ophthalmology ◽

10.1177/2515841421997195 ◽

2021 ◽

Vol 13 ◽

pp. 251584142199719

Author(s):

Burcu Polat Gultekin ◽

Esra Sahli

Keyword(s):

Confidence Interval ◽

Optical Density ◽

Central Serous Chorioretinopathy ◽

Choroidal Thickness ◽

Retinal Thickness ◽

Macular Pigment ◽

Central Retinal Thickness ◽

Macular Pigment Optical Density ◽

Chronic Central Serous Chorioretinopathy ◽

Acute Central Serous Chorioretinopathy

Purpose: The aim of our study was to evaluate the macular pigment optical density in patients with acute and chronic central serous chorioretinopathy and to describe the association between central retinal thickness and choroidal thickness with the macular pigment optical density. Materials and Methods: Eyes with acute central serous chorioretinopathy and chronic central serous chorioretinopathy (patients, who were diagnosed as having disease activity for 6 months) were included in this study. Macular pigment was measured using the heterochromatic flicker technique of the MPS II device for both eyes in patients with acute and chronic central serous chorioretinopathy and in control subjects. Results: Twenty-seven eyes with acute central serous chorioretinopathy, 23 eyes with chronic central serous chorioretinopathy, and 25 control eyes were enrolled. The mean macular pigment optical density in chronic central serous chorioretinopathy (0.480 ± 0.16 density unit (95% confidence interval: 0.390–0.570) was found to be significantly lower than in the control eyes (0.571 ± 0.128 density unit) (95% confidence interval: 0.480–0.670) ( p = 0.007). In correlation analysis, no significant association was detected between the central retinal thickness, choroidal thickness, and macular pigment optical density values in central serous chorioretinopathy group ( p = 0.31, p = 0.71). Conclusion: Macular pigment optical density levels were significantly lower in chronic central serous chorioretinopathy patients than in controls, possibly due to degeneration of the neurosensorial retina, as a result of the long-term persistence of subretinal fluid. There was not a significant correlation between choroidal thickness and macular pigment optical density levels in central serous chorioretinopathy group.

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