scholarly journals OCT-angiography detects longitudinal microvascular changes in glaucoma: a systematic review

2021 ◽  
pp. bjophthalmol-2020-318166
Author(s):  
Ana Miguel ◽  
André Silva ◽  
Joao Barbosa-Breda ◽  
Luis Azevedo ◽  
Abdulkarim Abdulrahman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Meta Analysis ◽  
Glaucoma Surgery ◽  
Oct Angiography ◽  
Optical Coherence ◽  
Longitudinal Changes ◽  
Microvascular Changes ◽  
Meta Analyses

Background/aimsOptical coherence tomography angiography (OCTA) allows the study of vessel density (VD). We intended to perform a systematic review of studies focusing on longitudinal changes in peripapillary and macular VD measurements in glaucoma.MethodsA search was performed across MEDLINE, Scopus, ISI Web of Science and Google Scholar, using the following query from inception until 20 September 2019: ((“optical coherence tomography angiography”[tiab]) OR (optical coherence tomography angiography[MeSH]) OR (“OCTA”[tiab]) OR (“OCT-A”[tiab]) OR (“angio-OCT”[tiab]) OR (“OCT- angiography”[tiab]) OR (“OCT-angio”[tiab]) OR (“OCT-angiographie”[tiab])) AND (glaucom*[tiab] OR glaucoma[MeSH]). Prospective studies that quantitatively assessed the longitudinal changes in VD in glaucoma with at least 3 months of follow-up were included.ResultsTen out of 4516 studies were included. The rate of VD change in glaucoma varied from 0.036/year to 1.08/year and 1.3% to 3.2% per year, with significantly different rates between glaucoma and healthy controls. Five studies assessed VD change after glaucoma surgery, obtaining variable results, ranging from a temporary VD decrease to increase after 3 months. Meta-analysis was not possible due to a wide variation in methods, measurements and region of VD.ConclusionOCTA is a non-invasive technology, which shows promise in glaucoma. Measures should be taken to increase the quality and standardise the methodology of VD measures in OCTA longitudinal studies, for future meta-analyses.

scholarly journals Diagnostic value of optical coherence tomography angiography for choroidal neovascularization in age-related macular degeneration: A systematic review and meta-analysis

2020 ◽  
Author(s):  
Chang-Xi Chen ◽  
Mei-Ling Liu ◽  
Kai Cao ◽  
Mayinuer Yusufu ◽  
Jin-Da Wang
Keyword(s):  
Systematic Review ◽  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Choroidal Neovascularization ◽  
Optical Coherence Tomography Angiography ◽  
Meta Analysis ◽  
Diagnostic Value ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Classification Rate

Objective: To evaluate the diagnostic value of optical coherence tomography angiography (OCTA) in detecting the choroidal neovascularization (CNV) in agerelated macular degeneration (AMD). Methods: A systematic review and meta-analysis was performed by searching Pubmed, Science Direct, Embase and Web of Science. The pooled sensitivity and specificity with 95% confidence intervals (CIs), area under the summary receiver operator characteristic curve (sROC), and the total accurate classification rate were used to evaluate OCTA’ diagnostic value of CNV in AMD patients. Results: Seven studies involving 517 eyes were included in the analysis. The mean age of subjects in each study ranged from 58.5 years to 81.7 years. Fluorescein angiography was applied as the gold standard in five studies. There were 350 eyes diagnosed with CNV, OCTA detected 301 eyes correctly, while among the 167 eyes without CNV, OCTA identified 150 correctly. The total accurate classification rate was 87.23%. The Spearman's rank correlation coefficient was 0.5, indicating that there was no significant threshold effect in the current study (S=8, p=0.103). The pooled sensitivity and pooled specificity were 0.89 (95%CI: 0.82,0.94) and 0.96 (95%CI: 0.85,1.00) respectively. The area under sROC was up to 0.911. Conclusion: The specificity of OCTA for the detection of CNV in AMD patients is extremely high, however, the sensitivity still needs to be improved. In general, the metaanalysis revealed that OCTA had a high diagnostic value for the detection of CNV in AMD patients.

Diagnostic performance of optical coherence tomography angiography in glaucoma: a systematic review and meta-analysis

2019 ◽  
Vol 103 (11) ◽  
pp. 1677-1684 ◽  
Author(s):  
Ana I M Miguel ◽  
André B Silva ◽  
Luis F Azevedo
Keyword(s):  
Systematic Review ◽  
Optical Coherence Tomography ◽  
Prospective Studies ◽  
Diagnostic Performance ◽  
Optical Coherence Tomography Angiography ◽  
Meta Analysis ◽  
Optical Coherence ◽  
Manual Search ◽  
Significant Difference ◽  
The Mean

BackgroundCompared with current imaging methods, the diagnostic performance and the advantages and limitations of optical coherence tomography angiography (OCTA) remain unclear. We performed a systematic review and meta-analysis of studies investigating vessel density (VD) in patients with glaucoma using OCTA.MethodsWe conducted a literature search on PubMed, Scopus, Web of Science, ISI Conference Proceedings and Google Scholar, along with a manual search, from January 2006 to March 2018. We included prospective studies that used OCTA to compare the VD in glaucomatous eyes with healthy control eyes.ResultsOf 3045 screened articles, 24 were included in a broad characterisation and 18 in the meta-analysis. We observed a statistically significant reduction in the mean peripapillary VD (MPVD) in glaucoma (MPVD: 57.53%, 95% CI 52.60 to 62.46, p< 0.001) compared with controls (MPVD: 65.47%, 95% CI 59.82 to 71.11; standardised mean difference [SMD], –1.41, 95% CI –1.62 to –1.20, p< 0.001) for 888 glaucomatous and 475 healthy eyes, and also in the mean-whole optic nerve image VD (SMD, –9.63, 95% CI –10.22 to –9.03, p<0.001), mean inside-disc VD (SMD, − 9.51, 95% CI –12.66 to –6.36, p<0.05) and mean parafoveal VD (SMD, –3.92, 95% CI –4.73 to –3.12, p<0.001). Subgroup analyses revealed a significant difference in the MPVD across glaucoma subtypes and OCTA devices.ConclusionThis suggests the diagnostic utility of OCTA in detecting glaucomatous eyes; however, further longitudinal prospective studies are welcomed to characterise vascular changes in glaucoma.

scholarly journals Test performance of optical coherence tomography angiography in detecting retinal diseases: a systematic review and meta-analysis

Eye ◽  
2019 ◽  
Vol 33 (8) ◽  
pp. 1327-1338 ◽  
Author(s):  
Livia Faes ◽  
Nicolas S. Bodmer ◽  
Silvan Locher ◽  
Pearse A. Keane ◽  
Konstantinos Balaskas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Optical Coherence Tomography ◽  
Test Performance ◽  
Optical Coherence Tomography Angiography ◽  
Meta Analysis ◽  
Retinal Diseases ◽  
Optical Coherence

Optical coherence tomography angiography in Alzheimer’s disease: a systematic review and meta-analysis

Eye ◽  
2021 ◽  
Author(s):  
Andreas Katsimpris ◽  
Aristotelis Karamaounas ◽  
Anna Maria Sideri ◽  
John Katsimpris ◽  
Ilias Georgalas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Meta Analysis ◽  
Optical Coherence

scholarly journals The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Wilson Tan ◽  
Xinwen Yao ◽  
Thu-Thao Le ◽  
Anna C. S. Tan ◽  
Carol Y. Cheung ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Meta Analysis ◽  
Mean Difference ◽  
Vessel Density ◽  
Foveal Avascular Zone ◽  
Systemic Hypertension ◽  
Optical Coherence ◽  
Microvascular Changes ◽  
Capillary Plexus

Objective: Multiple studies have compared various optical coherence tomography angiography (OCTA) parameters in participants with systemic hypertension vs. controls and have presented discordant findings. We conducted a meta-analysis to pool together data from different studies to generate an overall effect size and find out whether OCTA parameter(s) significantly differed in participants with systemic hypertension as compared to controls.Methods: We conducted a literature search through a search of electronic databases to identify studies before 19 June 2021, which compared OCTA parameters in non-diabetic participants with systemic hypertension vs. controls. If the OCTA parameter had a minimum number of 3 studies that analyzed it, the mean difference between participants with systemic hypertension and controls were analyzed using a random-effects model.Results: We identified 11 eligible studies. At the macula, 9 studies analyzed vessel density at the superficial capillary plexus (SVD), 7 analyzed vessel density at the deep capillary plexus (DVD), and 6 analyzed the area of the superficial foveal avascular zone (FAZ). Participants with systemic hypertension had significantly lower SVD (standardized mean difference [SMD], −0.50 [−0.70, −0.30], P &lt; 0.00001, I2 = 63%), lower DVD (SMD, −0.38 [−0.64, −0.13], P = 0.004, I2 = 67%) and larger superficial FAZ (SMD, 0.32 [0.04, 0.61], P = 0.020, I2 = 77%).Conclusion: The eyes of people with systemic hypertension have robustly lower superficial and deep vascular densities at the macula when compared to control eyes. Our results suggest that OCTA can provide information about pre-clinical microvascular changes from systemic hypertension.

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